Cholinergic Regulation of Sleep and Circadian Rhythms

睡眠和昼夜节律的胆碱能调节

• 批准号: 6946833
• 负责人: Sabra M Abbott
• 金额: $ 7.48万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-09 至 2008-08-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946833
• 关键词: REM sleep; acetylcholine; anticholinergic agent; atropine; behavior test; biological clocks; brain stem; carbachol; cholinergic agents; circadian rhythms; electrostimulus; ethology; laboratory rat; male; neurochemistry; neuropharmacology; neurophysiology; neuroregulation; predoctoral investigator; sleep; sleep deprivation; suprachiasmatic nucleus

DESCRIPTION (provided by applicant): The central pacemaker for mammalian circadian rhythms, the suprachiasmatic nucleus (SCN), receives a wide variety of neurochemical inputs, including cholinergic projections originating in the brainstem and the basal forebrain. The circadian pattern of cholinergic influence and the role of this signal in the functioning of the SCN are still being determined. Early data suggested that acetylcholine caused phase delays in wheel running behavior when applied early in the night, and phase advances when applied late in the night, similar to the response seen following light exposure. However in vitro evidence in both rats and mice indicates that when cholinergic agonists are applied directly to the SCN, either in vivo or in vitro, they cause phase advances throughout the night, with a maximal response at circadian time (CT) 18 in rats and CT 20 in mice. This proposal will attempt to further characterize the cholinergic influence on the SCN, and test the hypothesis that this cholinergic input plays a role in regulating the sleep-wake and circadian cycles of the animal.

描述（由申请人提供）： 哺乳动物昼夜节律的中央起搏器，上核（SCN）接收了多种神经化学输入，包括胆碱能投影，源自脑干和基础前脑。昼夜节律的胆碱能影响模式以及该信号在SCN功能中的作用仍在确定。早期数据表明，乙酰胆碱在深夜应用时会导致车轮跑步行为的相位延迟，并在深夜应用时进行阶段进展，类似于暴露后看到的响应。然而，大鼠和小鼠的体外证据表明，当直接在体内或体外施用胆碱能激动剂时，它们会在整个夜晚引起相位的进展，而在昼夜节律时（CT）18的大鼠中的最大反应，小鼠的CT 20。该提案将试图进一步表征胆碱能对SCN的影响，并检验该胆碱能输入在调节动物的睡眠效果和昼夜节律中起作用的假设。