Cholinergic regulation of a sensorimotor nucleus

感觉运动核的胆碱能调节

• 批准号: 6999927
• 负责人: TAL LEVIN
• 金额: $ 3.2万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999927
• 关键词: acetylcholine; anticholinergic agent; arousal; attention; auditory feedback; behavioral /social science research tag; biological models; cholinergic receptors; electrophysiology; histology; learning; male; neural information processing; neural transmission; neuroregulation; predoctoral investigator; prosencephalon; psychomotor function; sensorimotor system; sensory cortex; single cell analysis; songbirds; vocalization; voltage /patch clamp

DESCRIPTION (provided by applicant): Vocal learning in songbirds provides an attractive model system through which to study the neural mechanisms underlying behavior. Evidence from electrophysiological studies has shown that behavioral state is relevant to the regulation of auditory feedback, which is necessary for song learning and maintenance. Endogenous cholinergic release is able to modify the expression of auditory responses in a manner similar to that noted across behavioral states and selects between functionally distinct pathways in the song system. Our proposal aims to utilize in vitro electrophysiology to determine the effects of cholinergic tone on the network reconfiguration of a forebrain nucleus that is the nexus of premotor and auditory activity. While cholinergic mechanisms have been shown to be involved in sensory cortex reorganization, attention, arousal, and sensory modulation, the role of acetylcholine in sensorimotor processing is not well defined. The experiments proposed herein have the potential to illuminate the role of acetylcholine in network reconfiguration and sensorimotor processing in relation to an ethologically relevant learned motor behavior.

描述（由申请人提供）：鸣禽的声音学习提供了一个有吸引力的模型系统，通过该系统可以研究行为背后的神经机制。电生理学研究的证据表明，行为状态与听觉反馈的调节有关，这对于歌曲的学习和维持是必要的。内源性胆碱能释放能够以类似于跨行为状态注意到的方式改变听觉反应的表达，并在歌曲系统中功能不同的路径之间进行选择。我们的建议旨在利用体外电生理学来确定胆碱能张力对前脑核网络重构的影响，前脑核是前运动和听觉活动的联系。虽然胆碱能机制已被证明参与感觉皮层重组、注意力、唤醒和感觉调节，但乙酰胆碱在感觉运动处理中的作用尚不清楚。本文提出的实验有可能阐明乙酰胆碱在网络重构和感觉运动处理中与行为学相关的习得运动行为相关的作用。