Quantitative analysis of feedback during locomotion

运动过程中反馈的定量分析

• 批准号: 6885684
• 负责人: KYLA T ROSS
• 金额: $ 3.91万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-03 至 2006-12-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6885684
• 关键词: biomechanics; cats; chordate locomotion; gait; neuromuscular function; neuromuscular transmission; predoctoral investigator; psychomotor function; reflex

DESCRIPTION (provided by applicant): The goal of the proposed research is to map the distribution of heterogenic and autogenic feedback during locomotion and to determine their underlying mechanisms. To date, the role and distribution of these force-dependent and length-dependent pathways during locomotion remains largely unexplored and controversial. Force responses will be measured in quadriceps muscles and ankle extensors, such as the triceps surae and flexor hallicus longus muscles, during spontaneous locomotion and during the crossed-extension reflex within the same preparation. The goal is to ascertain whether feedback is modulated between the two states. Once the distribution of heterogenic feedback has been mapped among these muscles, autogenic feedback will be analyzed to determine the change in gain during stepping. Experimental methods employed to discern length and force effects include history dependence, vibration, and intramuscular stimulation. Because limitations are associated with each approach, several methods will be completed to determine the contribution of length and force feedback to the change in autogenic gain. This proposed research will not only determine the neural connections between and among these muscles, but also will explore the functional relevance for the feedback pathways from a biomechanical perspective. Determining the contribution of this neural feedback during locomotion is essential for effective rehabilitation of patients with motor deficits, including spinal cord injury.

描述（由申请人提供）：拟议研究的目的是绘制运动过程中异质和自体反馈的分布，并确定其潜在机制。迄今为止，在运动期间这些力依赖性和长度依赖性途径的作用和分布在很大程度上没有探索和有争议。力反应将在自发的运动期间以及在相同的制剂中在自发的运动过程中以及在交叉延伸的反射期间，在股四头肌肌肉和脚踝伸肌中测量。目的是确定在两个状态之间是否调制反馈。一旦在这些肌肉中映射了异质反馈的分布，将分析自源反馈，以确定步进过程中增益的变化。用于辨别长度和力效应的实验方法包括病史依赖，振动和肌肉内刺激。由于限制与每种方法相关联，因此将完成几种方法，以确定长度和力反馈对自动增益变化的贡献。这项提出的研究不仅将确定这些肌肉之间和之间的神经联系，而且还将从生物力学的角度探索反馈途径的功能相关性。确定运动过程中这种神经反馈的贡献对于有效康复运动缺陷患者（包括脊髓损伤）至关重要。