Spinal Control of Locomotion: Studies and Applications

脊髓运动控制：研究与应用

• 批准号: 7071506
• 负责人: Ilya A Rybak
• 金额: $ 46.84万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-03 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7071506
• 关键词: bioinformatics; biomechanics; brain electronic stimulator; cats; chordate locomotion; computational biology; computational neuroscience; decerebration; electromyography; electronic stimulator; electrostimulus; gait; interdisciplinary collaboration; limb movement; model design /development; musculoskeletal system; neuroanatomy; neuromuscular function; neuromuscular stimulator; neuromuscular system; neuromuscular transmission; neuroregulation; spinal cord; spine injury

DESCRIPTION (provided by applicant): This Bioengineering Partnership brings together a multidisciplinary team of neuroscientists and engineers with complementary expertise in neural organization of the spinal cord (Dr. David McCrea, University of Manitoba), biomedical engineering and neuromuscular stimulations (Dr. Michel Lemay, Drexel University), physiology and biomechanics of locomotion (Dr. Boris Prilutsky, Georgia Institute of Technology), and computational neuroscience and neural control (Dr. llya Rybak, Drexel University). The goals of this project are (1) to perform a comprehensive multidisciplinary study of neural mechanisms in the mammalian spinal cord responsible for generation of the locomotor pattern and control of locomotion and (2) to find optimal strategies for restoring locomotor function after spinal cord injuries. In this project, two comprehensive databases will be created based on experimental studies of fictive locomotion in the decerebrate cat and on biomechanical studies of freely moving uninjured cats and spinal cats. These databases will be used for the development of (1) a computational model of neural circuitry of the spinal cord responsible for generation and control of the locomotor pattern and (2) a neuro-musculo-skeletal model of cat's locomotion. Special quantitative biomechanical criteria will be developed for evaluation of locomotor capabilities of spinal cats during and after implementation of different treatments for restoring the locomotor function. The computational models and biomechanical criteria developed will provide guidance for the applied treatments and evaluation of their results. Different strategies for the restoration of locomotor capabilities based on the combination of locomotor training on a treadmill with phase-dependent electrical stimulation of the selected sensory afferents will be implemented and investigated. The results of this project will provide significant insights into spinal mechanisms responsible for control of locomotion and will represent an important step toward the development of optimal and effective methods for restoration of locomotor function after various spinal cord injuries.

DESCRIPTION (provided by applicant): This Bioengineering Partnership brings together a multidisciplinary team of neuroscientists and engineers with complementary expertise in neural organization of the spinal cord (Dr. David McCrea, University of Manitoba), biomedical engineering and neuromuscular stimulations (Dr. Michel Lemay, Drexel University), physiology and biomechanics of locomotion (Dr. Boris Prilutsky，佐治亚理工学院和计算神经科学与神经控制（Drexel University Llya Rybak博士）。该项目的目标是（1）对负责产生运动模式和移动控制的哺乳动物脊髓中神经机制进行全面的多学科研究，以及（2）找到脊髓损伤后恢复运动运动功能的最佳策略。在该项目中，将基于对脑猫的虚拟运动的实验研究以及对自由移动的不受伤害的猫和脊柱猫的生物力学研究创建两个综合数据库。这些数据库将用于开发（1）负责发射和控制运动模式的脊髓的神经回路的计算模型，以及（2）CAT运动的神经肌肉骨骼模型。将开发特殊的定量生物力学标准，以评估在实施不同处理过程中脊柱猫的运动能力以恢复运动功能。开发的计算模型和生物力学标准将为应用治疗和评估其结果提供指导。基于跑步机上的运动训练与相关的感官传统的相关电刺激的结合，将实施和研究不同的策略，以恢复运动能力。该项目的结果将提供对负责控制运动的脊柱机制的重大见解，并将代表着开发各种脊髓损伤后恢复运动功能的最佳和有效方法的重要步骤。