CROSS BRIDGE MODELS OF HETEROGENEOUS MUSCLE FIBERS

异质肌纤维的跨桥模型

基本信息

批准号：
6186714
负责人：
DAVID C LIN
金额：
$ 2.63万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/6186714
关键词：
biological models biomechanics cats chordate locomotion crosslink mechanical pressure muscle function myofibrils posture proprioception /kinesthesia

项目摘要

The long-term objective of this training proposal is to gain an understanding of the basic physiological mechanisms contributing to the force generating properties of muscle, specifically for heterogeneous single muscle fibers. To this end, the goal of Specific Aim 1 is to determine the parameters of a cross-bridge model, the Distributed Moment (DM) muscle model, for each of the four fiber types. An identification procedure will use the experimentally obtained mechanical measures in single type-identified fibers including force-velocity, stiffness, and yielding properties at various levels of activation. These muscle models will be used in Specific Aim 2 to understand which factors and mechanisms represented in the model are important during physiologically realistic mechanical conditions. Specifically, the effects of movement history on stiffness and yielding properties will be studied. Moreover, the model will be validated by the accurate prediction of the mechanical response under those conditions. The clinical significance of this proposal is that the documented biochemical fiber type alterations (muscle plasticity), which occur in the pathology of muscle, can be used in conjunction with fiber type based cross-bridge models to predict changes in muscle force generating properties.

该培训建议的长期目标是获得了解有助于促进的基本生理机制肌肉的力产生特性，专门针对异质单肌纤维。为此，特定目标的目标1是确定跨桥模型的参数，分布矩（DM）肌肉模型，适用于四种纤维类型中的每一种。标识程序将使用实验中获得的机械措施单型识别的纤维，包括力速度，刚度和在各种激活水平下产生特性。这些肌肉模型将用于特定目标2，以了解哪些因素和模型中代表的机制在生理上很重要现实的机械条件。具体而言，运动的影响将研究有关刚度和屈服特性的历史。而且，该模型将通过机械的准确预测来验证在这些条件下的响应。临床意义建议是记录的生化纤维类型的改变（肌肉可塑性）发生在肌肉的病理中，可以是与基于纤维类型的跨桥模型一起使用肌肉力产生特性的变化。