Biomechanics of spinal manipulation using a cat model

使用猫模型进行脊柱操纵的生物力学

• 批准号: 7091538
• 负责人: ALLYSON IANUZZI
• 金额: --
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-02-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7091538
• 关键词: alternative medicine; backache; biological models; biomechanics; cats; computational biology; human data; mathematics; neurophysiology; predoctoral investigator; spine; alternative medicine; backache; biological models; biomechanics; cats; computational biology; human data; mathematics; neurophysiology; predoctoral investigator; spine

DESCRIPTION (provided by applicant): Spinal manipulation (SM) is an effective treatment for low back pain, though the mechanisms by which it is effective remain elusive. It has been theorized that SM initiates a beneficial neurophysiological response by stimulating mechanically sensitive neurons in the facet joint capsule (FJC). The neurophysiological response during SM-like loads has been investigated in cat models, while the biomechanics of SM have been studied mostly in humans during in vivo or cadaveric studies. These data are not easily related because little is known about how the biomechanical response of the human lumbar spine during SM relates to that of the cat. The specific aim of the proposed study is to determine the mathematical relationship between the mechanical states of human and cat lumbar FJCs during SM. Cat cadaveric spines will be mechanically tested during simulated physiological motions and SM. A mathematical relationship will be established to relate cat lumbar FJC strain magnitudes to those obtained from prior studies in human cadaveric lumbar spines. Using this scaling relationship, the neurophysiological data obtained from cat models in future studies can be used to estimate how biomechanically similar motions would affect human FJC afferents.

描述（由申请人提供）：脊柱操纵（SM）是对腰痛的有效治疗方法，尽管其有效的机制仍然难以捉摸。从理论上讲，SM通过刺激刻布关节囊（FJC）中的机械敏感神经元来启动有益的神经生理反应。在CAT模型中已经研究了SM样载荷期间的神经生理反应，而SM的生物力学在体内或尸体研究期间主要是在人类中研究的。这些数据不容易相关，因为对SM期间人类腰椎的生物力学反应与猫的生物力学反应几乎没有知识。拟议的研究的具体目的是确定SM期间人类和猫腰FJC机械状态之间的数学关系。在模拟的生理运动和SM中，将对CAT尸体刺进行机械测试。将建立数学关系，以将CAT腰FJC菌株的幅度与从人尸体腰脊柱中获得的研究相关联。使用这种缩放关系，可以使用从CAT模型中获得的神经生理数据来估计生物力学相似的运动如何影响人类FJC传统。