Biomechanics of spinal manipulation using a cat model

使用猫模型进行脊柱操纵的生物力学

• 批准号: 7091538
• 负责人: ALLYSON IANUZZI
• 金额: --
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-02-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7091538
• 关键词: alternative medicine; backache; biological models; biomechanics; cats; computational biology; human data; mathematics; neurophysiology; predoctoral investigator; spine

DESCRIPTION (provided by applicant): Spinal manipulation (SM) is an effective treatment for low back pain, though the mechanisms by which it is effective remain elusive. It has been theorized that SM initiates a beneficial neurophysiological response by stimulating mechanically sensitive neurons in the facet joint capsule (FJC). The neurophysiological response during SM-like loads has been investigated in cat models, while the biomechanics of SM have been studied mostly in humans during in vivo or cadaveric studies. These data are not easily related because little is known about how the biomechanical response of the human lumbar spine during SM relates to that of the cat. The specific aim of the proposed study is to determine the mathematical relationship between the mechanical states of human and cat lumbar FJCs during SM. Cat cadaveric spines will be mechanically tested during simulated physiological motions and SM. A mathematical relationship will be established to relate cat lumbar FJC strain magnitudes to those obtained from prior studies in human cadaveric lumbar spines. Using this scaling relationship, the neurophysiological data obtained from cat models in future studies can be used to estimate how biomechanically similar motions would affect human FJC afferents.

描述（由申请人提供）：脊柱推拿（SM）是治疗腰痛的有效方法，但其有效机制仍不清楚。据推测，SM 通过刺激小关节囊 (FJC) 中的机械敏感神经元来启动有益的神经生理反应。类似 SM 负载期间的神经生理学反应已在猫模型中进行了研究，而 SM 的生物力学主要在人体或尸体研究中进行了研究。这些数据不容易关联起来，因为我们对 SM 期间人类腰椎的生物力学反应与猫的生物力学反应如何相关知之甚少。本研究的具体目的是确定 SM 期间人类和猫腰椎 FJC 的机械状态之间的数学关系。猫尸体脊柱将在模拟生理运动和 SM 过程中进行机械测试。将建立数学关系，将猫腰椎 FJC 应变大小与先前对人类尸体腰椎的研究获得的应变大小联系起来。利用这种比例关系，在未来的研究中从猫模型获得的神经生理学数据可用于估计生物力学上相似的运动将如何影响人类 FJC 传入。

项目成果

3-Methoxy-4-(4-nitro-benz-yloxy)-benzaldehyde.

3-甲氧基-4-(4-硝基-苯甲氧基)-苯甲醛。

• DOI: 10.1107/s1600536808036015
• 发表时间: 2008
• 期刊: Acta crystallographica. Section E, Structure reports online
• 作者: Li,Mei;Chen,Xin
• 通讯作者: Chen,Xin