Genetic Analysis of Attention Deficit Hyperactivity Diso

注意力缺陷多动症的遗传分析

• 批准号: 6681629
• 负责人: Maximilian Muenke
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6681629
• 关键词: Hispanic Americans; attention deficit disorder; behavioral /social science research tag; behavioral genetics; blood chemistry; clinical research; computer simulation; congenital brain disorder; expression cloning; family genetics; gene expression; generation difference; genome; human genetic material tag; human subject; impulsive behavior; linkage mapping; longitudinal human study; psychological tests; quantitative trait loci; siblings

Attention Deficit Hyperactivity Disorder (ADHD) is a genetically influenced brain disorder with a prevalence of 3-5% in school-age children. A genome-wide search for loci linked to ADHD has been initiated. To this end, affected sibling pairs and densely affected multi-generation Hispanic families have been recruited. Participating individuals undergo a battery of psychological tests and have blood drawn for the linkage analysis and positional cloning studies that are being used to search for genes associated with ADHD. To date, we have complete information on 15 large, multi-generation Hispanic families. Simulation studies on 27 informative pedigrees indicate excellent power to detect linkage (Arcos-Burgos et al., 2002).

注意力缺陷多动障碍 (ADHD) 是一种受遗传影响的脑部疾病，学龄儿童的患病率为 3-5%。与多动症相关的基因座的全基因组搜索已经启动。为此，已经招募了受影响的兄弟姐妹和受影响严重的多代西班牙裔家庭。参与的个体接受一系列心理测试，并抽血进行连锁分析和定位克隆研究，这些研究用于寻找与多动症相关的基因。迄今为止，我们掌握了 15 个多代西班牙裔大家庭的完整信息。对 27 个信息丰富的谱系的模拟研究表明检测连锁的能力极强（Arcos-Burgos 等，2002）。