Quantitative Vascular Image Analysis system

定量血管图像分析系统

• 批准号: 6736509
• 负责人: THOMAS CLEMENT
• 金额: $ 47.92万
• 依托单位: PATHWAY MEDICAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736509
• 关键词: atherosclerotic plaque; bioimaging /biomedical imaging; carotid artery; cerebrovascular imaging /visualization; clinical research; computer program /software; computer system design /evaluation; human subject; inflammation

DESCRIPTION (provided by applicant): Atherosclerosis is the root cause behind most heart attacks and strokes, making it the number one cause of mortality and morbidity in the United States. Methods are needed that permit evaluation of atherosclerotic lesion composition and morphology in vivo, thereby enabling medical professionals to base treatment decisions on accurate risk assessments and facilitating pharmaceutical trials that evaluate drug effects directly on the lesions. The goal of this application is to help meet these needs by establishing product lines for imaging and analyzing atherosclerosis in vivo. Our strategy is to develop and market the complete set of products necessary to evaluate a target vessel. Then, with a single purchase of a bundled package, the medical professional can convert a generic imaging device into an advanced atherosclerosis-imaging suite. One such suite will include, for example, specially designed phased-array coils for high-resolution Magnetic Resonance Imaging (MRI) of carotid arteries, a head holder, a guide to MRI techniques for the carotid arteries, and a Quantitative Vascular Analysis System (QVAS TM) for computer-based evaluation of the imaging results. This proposal addresses the last component in this list, the QVAS TM system. To enable us to meet this goal, we have established a strategic relationship with the Vascular Imaging Laboratory (VIL) at the University of Washington. With the assistance of the VIL, we have previously developed a prototype version of the QVAS TM software under Phase I SBIR grant R43-HL70576. By continuing this collaborative effort within this proposal, we plan to establish the QVAS TM system as the premier analysis tool for carotid artery disease.

描述（由申请人提供）： 动脉粥样硬化是大多数心脏病发作和中风的根本原因，使其成为美国死亡率和发病率的第一名。需要方法可以在体内评估动脉粥样硬化病变组成和形态，从而使医疗专业人员可以基于准确的风险评估并促进直接评估药物对病变影响的药物治疗基础治疗决策。 该应用的目的是通过建立用于成像和分析体内动脉粥样硬化的产品线来帮助满足这些需求。我们的策略是开发和销售评估目标船所需的完整产品集。然后，通过一次购买捆绑的软件包，医学专家可以将通用成像装置转换为高级动脉粥样硬化成像套件。一个这样的套件将包括，例如，用于颈动脉的高分辨率磁共振成像（MRI）的专门设计的阵列线圈，头持有人，颈动脉动脉的MRI技术指南以及定量血管分析系统（QVAS TM）的一项基于计算机的计算机评估。该提案解决了此列表中的最后一个组件，即QVAS TM系统。 为了使我们能够实现这一目标，我们已经与华盛顿大学的血管成像实验室（VIL）建立了战略关系。在VIL的帮助下，我们以前在I阶段I SBIR Grant R43-HL70576下开发了QVAS TM软件的原型版本。通过在该提案中继续进行这种协作努力，我们计划建立QVAS TM系统作为颈动脉疾病的主要分析工具。