Family Study of African Americans

非裔美国人的家庭研究

• 批准号: 6982838
• 负责人: kathleen r merikangas
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6982838
• 关键词: African American; alcoholism /alcohol abuse; anxiety disorders; behavioral /social science research tag; child behavior disorders; comorbidity; disease /disorder proneness /risk; family structure /dynamics; genetic susceptibility; human subject; psychopathology; socioenvironment; statistics /biometry

This was a five year study of black children ages 8-17 at high and low risk for alcohol-related problems based on a history of parental alcoholism. A prospective design was used to identify the specific disorders for which these children are at heightened vulnerability, and salient risk and protective processes in the development of the various types of childhood disorders. The major goals of the study were: 1. to examine the extent and patterns of psychopathology and behavioral problems among the offspring ages 8-17 of black alcoholic parents; 2. to assess the role of familial transmission of alcohol abuse/dependence and comorbid psychopathology, including substance abuse/dependence, in the pathogenesis of alcohol abuse in children; and 3. to identify multiple risk and protective indices of the pathogenesis of alcohol problems in black youth in order to yield information on the key targets of prevention and intervention. The key features of the study were: the sample of black alcohol abusers with young children about which there are sparse data; the epidemiologic source of the sample, which strengthened the generalizability of the findings and minimizes the bias in ascertainment of minorities from specialty treatment settings; the application of an epidemiologic family study paradigm, which permitted assessment of factors associated with familial transmission of risk factors and the mechanisms thereof; evaluation of the role of comorbidity of anxiety disorders and alcoholism in the transmission of alcohol-related problems; comprehensive assessment of vulnerability factors from broad domains or risk encompassing personal, family, and environmental attributes including community violence; the provision of knowledge essential for prevention through the assessment of protective factors which may inhibit pathogenic processes among children at high risk. Data collection of this study was completed at Yale University before the Principal Investigator?s relocation to the NIMH. The resources of our section have been devoted to preparation of these data for analysis and subsequent publications. This research provides a model for conducting studies of social epidemiology of mental disorders and substance abuse. During the past year, we have completed data cleaning and coding. The data are now ready for statistical analyses of the key study questions.

这是一项针对 8 至 17 岁黑人儿童进行的为期五年的研究，研究对象是酒精相关问题的高风险和低风险儿童，基于父母的酗酒史。采用前瞻性设计来确定这些儿童最容易罹患的特定疾病，以及各种类型儿童疾病发展过程中的显着风险和保护过程。 该研究的主要目标是： 1. 检查黑人酗酒父母的 8-17 岁后代的精神病理学和行为问题的程度和模式； 2. 评估酒精滥用/依赖的家族传播和共病精神病理学（包括药物滥用/依赖）在儿童酒精滥用发病机制中的作用；和 3. 确定黑人青少年酒精问题发病机制的多种风险和保护指数，以便提供有关预防和干预关键目标的信息。 该研究的主要特点是： 样本是有幼儿的黑人酗酒者，但数据很少；样本的流行病学来源，这增强了研究结果的普遍性，并最大限度地减少了专业治疗环境中确定少数群体的偏差；应用流行病学家庭研究范式，可以评估与危险因素家族传播相关的因素及其机制；评估焦虑症和酗酒共病在酒精相关问题传播中的作用；对广泛领域的脆弱性因素或包括个人、家庭和环境属性（包括社区暴力）的风险进行全面评估；通过评估可能抑制高危儿童致病过程的保护因素，提供预防所需的知识。 本研究的数据收集是在首席研究员调往 NIMH 之前在耶鲁大学完成的。我们部门的资源专门用于准备这些数据以供分析和后续出版物。这项研究为开展精神障碍和药物滥用的社会流行病学研究提供了模型。在过去的一年里，我们完成了数据清理和编码工作。现在数据已准备好用于关键研究问题的统计分析。