Imacon 200 Ultra High-Speed Framing Camera System

Imacon 200 超高速分幅相机系统

• 批准号: 6731470
• 负责人: LAWRENCE A CRUM
• 金额: $ 38.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6731470
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; image processing; photography; ultrasound

DESCRIPTION (provided by applicant): The purpose of this application is to obtain funding to purchase an Imacon 200 high-speed camera system to be shared by 10 users (from 5 Universities) to pursue projects from 7 funded NIH grants. Our team of investigators conducts clinically relevant basic research of therapeutic and diagnostic ultrasound. Much of the work involves acoustic cavitation -- the formation, growth and violent collapse of bubbles -- on the scale of nanoseconds to milliseconds. Various tools are available for cavitation detection and quantification, but none is more powerful for visualizing bubbles in water than high-speed photography. We have managed to fund 3 brief rental periods during which we have collected data for 11 published papers. The Imacon 200 is the only camera capable of the spatial and temporal resolution, number of frames, and flexibility of adjustable inter-frame spacing required by our studies, but it is not for rent. The Imacon 200 will be available for shared use under the direction of the Camera Supervisor Dr. Lawrence Crum. Drs. Crum and Michael Bailey will use the camera to capture the shock wave interactions of the dual pulse lithotripter to characterize the lithotripter for potential in vivo use. Drs. Thomas Matula and Crum will image the response and rupture of echo contrast agents to identify acoustic parameters to optimize ultrasound image resolution. Dr. Tim Colonius plans to utilize camera images to verify a newly developed numerical predictor of bubble dynamics. Dr. Robin Cleveland looks to capture the acoustics and cavitation fields of new 3rd-generation lithotripters in an effort to correlate these characteristics with a recent decline in lithotripter efficacy and safety. Drs. Clyde Briant and Cleveland will investigate the rapid process of fracture in kidney stones. Dr. James McAteer will use the camera to find optimal parameters of voltage and rate of shock wave delivery in lithotripsy and Drs. James Williams and McAteer will record cavitation behavior in vitro under conditions that simulate the environment of the renal pelvis and kidney blood vessels to assess mechanisms of collateral damage in lithotripsy. Dr. Andrew Evan will observe cavitation activity in the kidney collecting system in vivo. Dr. Roy Martin hopes to capture the entrainment of bubbles, emulsification of blood, and the formation of a hemostatic paste in work to develop HIFU as a practical tool for trauma and surgical care.

描述（由申请人提供）： 此应用程序的目的是获得资金以购买iMacon 200高速相机系统，可由10个用户（来自5所大学）共享，以从7个资助的NIH赠款中寻求项目。我们的研究人员团队对治疗和诊断超声进行临床相关的基础研究。大部分工作涉及声气水 - 纳秒至毫秒到毫秒的尺度上的气泡 - 气泡的形成，生长和暴力崩溃。可以用于空化检测和量化各种工具，但是没有比高速摄影更强大，可以看到水中的气泡。我们设法资助了3个简短的租赁期，在此期间我们收集了11个已发表论文的数据。 iMacon 200是唯一能够使用空间和时间分辨率，帧数以及我们研究所需的可调节框架间间距的灵活性的相机，但这并不是为了出租。 iMacon 200将在摄像机主管劳伦斯·克鲁姆（Lawrence Crum）博士的指导下共享使用。博士。克鲁姆（Crum）和迈克尔·贝利（Michael Bailey）将使用摄像头捕获双脉冲岩石磨牙器的冲击波相互作用，以表征岩石夹器，以便在体内使用。博士。 Thomas Matula和Crum将对Echo对比剂的响应和破裂成像，以识别声学参数以优化超声图像分辨率。 Tim Colonius博士计划利用相机图像验证新开发的气泡动力学数值预测指标。罗宾·克利夫兰（Robin Cleveland）博士旨在捕捉新的第三代岩石制片机的声学和空化场，以将这些特征与最近岩石纤维疗效和安全性的下降相关联。博士。克莱德·布里特（Clyde Briant）和克利夫兰（Cleveland）将研究肾结石裂缝的快速过程。詹姆斯·麦卡特（James McAteer）博士将使用摄像头找到岩石疗法和DRS中电压传递速率的最佳参数。詹姆斯·威廉姆斯（James Williams）和麦卡特（McAteer）将在模拟肾脏骨盆和肾脏血管环境的条件下在体外记录空化行为，以评估写岩石疗法的副外损伤机制。安德鲁·埃文（Andrew Evan）博士将在体内观察肾脏收集系统的气蚀活动。罗伊·马丁（Roy Martin）博士希望捕获泡沫的夹带，血液的乳化性以及在工作中形成止血糊，以发展HIFU作为创伤和手术护理的实用工具。