3 T Whole Body Magnetic Resonance Scanner

3T全身磁共振扫描仪

• 批准号: 6732435
• 负责人: PONNADA A NARAYANA
• 金额: $ 50万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2005-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6732435
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; functional magnetic resonance imaging; image processing; magnetic resonance imaging; neuroimaging; nuclear magnetic resonance spectroscopy; whole body imaging /scanning

DESCRIPTION (provided by applicant): This application seeks partial funding from NIH and NSF for purchasing a 3 Tesla, whole body magnetic resonance scanner for in vivo imaging (MRI) and spectroscopy (MRS) in humans and nonhuman primates. The scanner will be housed in the University of Texas Medical School at Houston, which is located in the Texas Medical Center, home of four major research institutions and five hospitals. This scanner will be equipped with body and head RF coils and high performance gradient system that is capable of producing maximum gradient amplitudes of 40 mT/m with a slew rate of 200 mT/m/s. In addition, it will incorporate five-second order room temperature shims for improved field homogeneity. This high performance system will allow us to implement advanced MR imaging techniques such as diffusion tensor imaging (DTI), functional MRI (fMRI), and spectroscopic imaging (MRSI). Processing software for DTI, fMRI, and MRSI (2D, 3D, multislice and with a variety of k-space scanning techniques) will be included with the scanner. A full research agreement with the manufacturer will be executed for access to all the source codes for the pulse sequences and reconstruction algorithm to modify the existing sequences and implement newer sequences on the scanner. These will be made available to all the users. In addition, the scanner will provide access to the raw data for testing advanced image processing techniques. This high field and high performance MR scanner will be used for investigating 1) various neurological disorders, 2) techniques for improving learning and development in normal school age children by fusing information from MRI and MEG, and 3) advanced automatic image processing. The neurological disorders that will be investigated include neurodevelopmental disorders in humans and nonhuman primates, psychiatric disorders, and demyelinating diseases such as multiple sclerosis. Twenty-one projects by fourteen users who are Pl's on NIH and NSF funded grants with significant MR component have been identified. While the main thrust of the proposed projects is neuroimaging, we anticipate that future projects would include body imaging, particularly cardiovascular imaging. Strong institutional commitment and financial plans for operating the scanner, particularly the long-term maintenance, are described.

描述（由申请人提供）： 该应用程序寻求NIH和NSF的部分资金，用于在人类和非人类灵长类动物中购买3泰斯拉，全身磁共振扫描仪，用于体内成像（MRI）和光谱（MRS）。该扫描仪将位于休斯敦的德克萨斯大学医学院，该学校位于德克萨斯州医疗中心，这是四家主要研究机构和五家医院的所在地。该扫描仪将配备车身和头部RF线圈和高性能梯度系统，该系统能够产生最大的梯度振幅为40 mt/m，其振荡速率为200 mt/m/m/s。此外，它将结合五秒钟的室温垫片，以提高现场均匀性。这种高性能系统将使我们能够实施高级MR成像技术，例如扩散张量成像（DTI），功能性MRI（fMRI）和光谱成像（MRSI）。扫描仪将包括用于DTI，fMRI和MRSI（2D，3D，Multislice以及各种K空间扫描技术）的处理软件。将执行与制造商的完整研究协议，以访问脉冲序列和重建算法的所有源代码，以修改现有序列并在扫描仪上实现新序列。这些将提供给所有用户。此外，扫描仪将提供对测试高级图像处理技术的原始数据的访问权限。这种高领域和高性能MR Scanner将用于研究1）各种神经系统疾病，2）通过融合MRI和MEG的信息，以及3）高级自动图像处理，用于改善正常学龄儿童学习和发展的技术。将研究的神经系统疾病包括人类和非人类灵长类动物，精神疾病和脱髓鞘疾病（如多发性硬化症）的神经发育障碍。已经确定了NIH的PL和NSF资助的具有重要MR组件的NSF资助的PL的21个项目。虽然拟议项目的主要目的是神经影像学，但我们预计未来的项目将包括身体成像，尤其是心血管成像。描述了强大的机构承诺和经营扫描仪的财务计划，特别是长期维护。

项目成果

Distinguishing and quantification of the human visual pathways using high-spatial-resolution diffusion tensor tractography.

• DOI: 10.1016/j.mri.2014.04.002
• 发表时间: 2014-09
• 期刊: MAGNETIC RESONANCE IMAGING
• 影响因子: 2.5
• 作者: Kamali, Arash;Hasan, Khader M.;Adapa, Pavani;Razmandi, Azadeh;Keser, Zafer;Lincoln, John;Kramer, Larry A.
• 通讯作者: Kramer, Larry A.

A neural basis for interindividual differences in the McGurk effect, a multisensory speech illusion.

• DOI: 10.1016/j.neuroimage.2011.07.024
• 发表时间: 2012-01-02
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Nath, Audrey R.;Beauchamp, Michael S.
• 通讯作者: Beauchamp, Michael S.

Contrast enhanced MR venography with gadofosveset trisodium: evaluation of the intracranial and extracranial venous system.

钆磷维三钠对比增强磁共振静脉造影：颅内和颅外静脉系统的评估。

• DOI: 10.1002/jmri.24409
• 发表时间: 2014
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Kramer,LarryA;Cohen,AlanM;Hasan,KhaderM;Heimbigner,JaredH;Barreto,AndrewD;Brod,StaleyA;Narayana,PonnadaA;Wolinsky,JerryS
• 通讯作者: Wolinsky,JerryS

Role of diffusion tensor imaging as an independent predictor of cognitive and language development in extremely low-birth-weight infants.

扩散张量成像作为极低出生体重婴儿认知和语言发展的独立预测因子的作用。

• DOI: 10.3174/ajnr.a3725
• 发表时间: 2014
• 期刊: AJNR. American journal of neuroradiology
• 作者: Pogribna,U;Burson,K;Lasky,RE;Narayana,PA;Evans,PW;Parikh,NA
• 通讯作者: Parikh,NA

Temporal lobe white matter asymmetry and language laterality in epilepsy patients.

• DOI: 10.1016/j.neuroimage.2009.10.055
• 发表时间: 2010-02-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Ellmore, Timothy M.;Beauchamp, Michael S.;Breier, Joshua I.;Slater, Jeremy D.;Kalamangalam, Giridhar P.;O'Neill, Thomas J.;Disano, Michael A.;Tandon, Nitin
• 通讯作者: Tandon, Nitin