9.4Tesla/310mm MR Imaging and Spectroscopy System

9.4Tesla/310mm 磁共振成像和光谱系统

基本信息

批准号：
6803675
负责人：
ALICE M WYRWICZ
金额：
$ 200万
依托单位：
NORTHSHORE UNIVERSITY HEALTHSYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2008-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6803675
关键词：
bioimaging /biomedical imaging biomedical equipment purchase functional magnetic resonance imaging

项目摘要

DESCRIPTION (provided by applicant): Scientists at the Center for Basic M.R. Research, Evanston, Illinois request partial funding support to purchase a 9.4T/305mm bore horizontal axis MR scanner to image rabbits, rats and mice. The imager will have actively shielded superconducting magnet and will be fitted with two integrated gradient -shim coils, dual channel RF transmitter and dual receiver system. The center has primary affiliation to Evanston Northwestern Healthcare and secondary affiliation to Northwestern University as a core facility of the Robert H. Lurie Cancer Center. Justification of the requested high field imager is based on the demand for higher spatial resolution, temporal resolution, signal to noise ratio and contrast to noise ratio in funded projects that cannot be met by the 4.7T imager currently in use. Support for the request is presented extensively in the form of data obtained at 4.7T and on a vertical axis Omega 400WB spectrometer that is no longer operational. Projects that will use the proposed imager are described under three sections based on the MR methodology employed: (i) functional imaging, (ii) diffusion tensor imaging, and (iii) novel approaches to contrast enhancement. Functional neuroimaging projects that use a conscious rabbit model include studies of learning, memory, aging, anesthesia and the relationship between BOLD fMRI and underlying neuronal activity. The 9.4T imager will benefit these projects by increasing BOLD contrast quadratically for small venuoles and capillaries with minimal contribution from the large vessels. The two-fold increase in SNR expected at 9.4T will allow structures in neuronal circuitry to be studied with greater spatial specificity. High spatial resolution on the order of 0.2mm3 or less is essential to study activation in structures such as cortical columns and cortical layers or those in the sensory-limbic-cerebellar system with specificity. Measurement of anisotropy by diffusion tensor imaging is employed by five projects to advance understanding of changes to the cellular environment in neurological disorders such as AD, ALS, MS, and hypoxia-ischemia. Anisotropy measurements in brain and spinal cord will greatly benefit from the increased SNR available at 9.4T since accuracy in these measurements is severely affected by poor SNR. High spatial resolution requirements in these studies which focus on substructures within gray and white matter compartments of the mouse spinal cord or CA1, CA3 and DG regions in mouse hippocampus can only be met by the increased sensitivity of the 9.4T imager. Research in the area of contrast agents focuses on developing target-specific agents to study cell migration and signaling and on overcoming limitations of paramagnetic agents at high magnetic fields. Strong institutional support for cost-sharing in the purchase of the imager is indicated. Scientific staff responsible for the instrument has expertise and experience in small animal imaging.

描述（由申请人提供）：伊利诺伊州埃文斯顿基本M.R. Research中心的科学家要求购买部分资金支持，以购买9.4T/305mm的钻孔水平轴Mr Scanner先生，以形象兔子，大鼠和老鼠。成像仪将积极屏蔽超导磁铁，并配备两个集成的梯度-SHIM线圈，双通道RF发射器和双接收器系统。该中心主要隶属于埃文斯顿西北医疗保健，并作为罗伯特·H·卢里癌症中心的核心设施往西北大学的二级隶属关系。所需的高现场成像仪的理由是基于对较高空间分辨率，时间分辨率，信号与噪声比的需求以及与当前使用的4.7T成像器无法满足的资助项目中的噪声比对比。对请求的支持以在4.7T和垂直轴欧米茄400WB光谱仪上获得的数据形式进行广泛表示，该数据不再运行。根据所采用的MR方法，在三个部分中描述了将使用所提出成像仪的项目：（i）功能成像，（ii）扩散张量成像和（iii）对比度增强的新方法。使用有意识的兔子模型的功能性神经影像学项目包括学习，记忆，衰老，麻醉以及大胆fMRI与基础神经元活动之间的关系。 9.4T成像仪将通过对小船只的小门和毛细血管的四倍增加大胆的对比度来使这些项目受益。预期在9.4T时的SNR增加的两倍将允许以更大的空间特异性研究神经元电路中的结构。高空间分辨率在0.2mm3或更小的阶段对于研究皮质柱和皮层层或具有特异性的感觉夹层系统中的结构的激活至关重要。通过五个项目，通过扩散张量成像来测量各向异性，以提高对AD，ALS，MS和低氧疾病等神经系统疾病中细胞环境变化的了解。大脑和脊髓中的各向异性测量将受益于9.4T的SNR可获得的，因为这些测量的准确性严重受SNR的严重影响。在这些研究中，高空间分辨率的要求仅通过9.4T成像仪的灵敏度来满足小鼠海马中小鼠脊髓或CA1，CA3和DG区域内的灰质和白质区域的子结构。对比剂领域的研究重点是开发靶标特异性药物来研究细胞迁移和信号传导以及高磁场上顺磁试剂的克服局限性。指出了在购买成像仪中为成本分担的强大机构支持。负责该工具的科学人员在小动物成像方面具有专业知识和经验。