White Matter Abnormalities in Bipolar Adolescents

双相情感障碍青少年的白质异常

• 批准号: 6830302
• 负责人: VIVIAN KAFANTARIS
• 金额: $ 8.04万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6830302
• 关键词: adolescence (12-20); bioimaging /biomedical imaging; bipolar depression; brain imaging /visualization /scanning; clinical research; human subject; magnetic resonance imaging; patient oriented research; three dimensional imaging /topography; white matter

DESCRIPTION (provided by applicant): This application for a Small Grant (R03) is from an independent investigator, who wishes to expand (but not change) her area of investigation to include neuroimaging of adolescents with bipolar disorder. The applicant is the principal investigator of an ongoing NIMH funded controlled longitudinal treatment study with bipolar adolescents "Treatment and Outcome of Early-Onset Bipolar Disorder" (1R01MH60845). There is ample support available to the PI to undertake neuroimaging studies in this population from experienced neuroimaging investigators at the North Shore-Long Island Jewish Health System. Neuroimaging studies have implicated white matter pathology in the neurobiology of bipolar disorder in the form of hyperintensities and functional abnormalities. In this pilot study we propose to use diffusion tensor imaging (DTI) to characterize possible abnormalities in the white matter connecting ventral brain regions that have been hypothesized to play a key role in the affective instability associated with bipolar disorder. Study participants will include 30 adolescents with Bipolar I disorder and 30 age, gender and IQ-matched healthy volunteers. Studies investigating the pathophysiology of bipolar disorder that involve this age group will include a greater number of first episode patients with a shorter duration of treatment. Recruitment for this proposed study will be facilitated by the PI's ongoing NIMH-funded longitudinal treatment study of bipolar adolescents.

描述（由申请人提供）：这份小额资助（R03）申请来自一位独立研究者，她希望扩大（但不改变）她的研究领域，以包括双相情感障碍青少年的神经影像学。申请人是一项正在进行的 NIMH 资助的双向情感障碍青少年对照纵向治疗研究“早发性双向情感障碍的治疗和结果”（1R01MH60845）的首席研究员。北岸长岛犹太卫生系统经验丰富的神经影像研究人员为 PI 提供了充足的支持，可以在该人群中进行神经影像研究。神经影像学研究表明白质病理学与双相情感障碍的神经生物学有关，表现为高信号和功能异常。在这项初步研究中，我们建议使用扩散张量成像（DTI）来表征连接腹侧大脑区域的白质中可能存在的异常，这些区域被假设在与双相情感障碍相关的情感不稳定中发挥着关键作用。研究参与者将包括 30 名患有 I 型双相情感障碍的青少年和 30 名年龄、性别和智商匹配的健康志愿者。涉及该年龄组的双相情感障碍病理生理学研究将包括更多治疗时间较短的首发患者。 PI 正在进行的由 NIMH 资助的双相情感障碍青少年纵向治疗研究将促进这项拟议研究的招募。