Neuroimaging of Children at Risk for Biopolar Disorder

有双向情感障碍风险的儿童的神经影像学

• 批准号: 6694109
• 负责人: KIKI D CHANG
• 金额: $ 17.45万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-12 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694109
• 关键词: adolescence (12-20); aspartate; attention; bioimaging /biomedical imaging; bipolar depression; brain imaging /visualization /scanning; cingulate gyrus; creatinine; emotions; functional magnetic resonance imaging; genetic susceptibility; human subject; interview; longitudinal human study; middle childhood (6-11); neuroimaging; neuropsychological tests; nuclear magnetic resonance spectroscopy; pathologic process; patient oriented research; postdoctoral investigator; prefrontal lobe /cortex; questionnaires

DESCRIPTION (provided by the applicant): The long-term objective of this Mentored Patient-Oriented Research Career Development (K23) Award is to develop the candidate's skills in patient-oriented clinical research so that he may become an independent researcher in the field of child mental health. Dr. Chang's specific goal is to gain proficiency in pediatric mood disorders research, specifically in the area of utilizing brain imaging techniques to elucidate neurobiological data correlated to clinical presentations of children and adolescents with bipolar disorder (BD). To accomplish this goal, the candidate will be mentored by experts in the field of neuroimaging, childhood and adult BD, and statistics and research design. The candidate furthermore will participate in educational activities in his department as well as formal coursework in the areas of cognitive neuroscience, brain imaging, and statistics. Finally, the candidate will carry out a research project closely aligned with his research training plan. The goal of the proposed research project is to gather longitudinal phenomenological and brain imaging data on child and adolescent offspring of parents with BD, who are at high risk for developing bipolar disorder. These at-risk children, some already with BD, and healthy controls will be assessed longitudinally over three years by brain functional magnetic resonance imaging (fMRI) and proton magnetic resonance spectroscopy (MRS). fMRI tasks will be related to emotion and attention, and proton MRS will be of bilateral dorsolateral prefrontal cortices (DLPFC), specifically assessing n-acetyl aspartate/creatinine (NAA/Cr) ratios. Phenomenology will be assessed through structured diagnostic interviews, clinician-rated scales, and patient-rated questionnaires. We hypothesize that (1) at-risk offspring already with BD at baseline will have differing areas of activation and deactivation than healthy controls, primarily in DLPFC and anterior cingulate cortex (ACC), (2) at-risk offspring with BD will have lower NAA/Cr ratios in bilateral DLPFC compared to healthy controls, and (3) at-risk offspring who develop BD in the course of this study will demonstrate a greater decrease in DLPFC NAA/Cr from baseline than controls and patterns of brain activation similar to those subjects already with BD, either at baseline or at three-year follow-up. Through conducting this research project and implementation of the research training plan, Dr. Chang plans to become an independent investigator in the field of pediatric BD and thus contributing to the current knowledge of the neurobiology and development of BD.

描述（由申请人提供）：本项目的长期目标 以患者为导向的研究职业发展 (K23) 奖旨在 培养候选人以患者为中心的临床研究技能，以便他能够 成为儿童心理健康领域的独立研究者。博士。 张的具体目标是精通儿科情绪障碍 研究，特别是利用脑成像技术领域 阐明与儿童临床表现相关的神经生物学数据 以及患有双相情感障碍（BD）的青少年。为了实现这一目标， 候选人将接受神经影像学、儿童医学领域专家的指导 和成人BD，以及统计和研究设计。该候选人还 将参加他所在部门的教育活动以及正式的活动 认知神经科学、脑成像等领域的课程作业 统计数据。最后，候选人将密切开展一个研究项目 与他的研究培训计划保持一致。拟议研究的目标 项目的目的是收集纵向现象学和脑成像数据 父母患有双相情感障碍的儿童和青少年后代，是罹患双相情感障碍的高风险人群 发展为双相情感障碍。这些高危儿童，其中一些已经患有双相情感障碍，并且 大脑将在三年内对健康对照进行纵向评估 功能磁共振成像 (fMRI) 和质子磁共振 光谱（MRS）。 fMRI 任务将与情绪和注意力相关，并且 质子 MRS 将针对双侧背外侧前额皮质 (DLPFC)， 特别评估 n-乙酰天冬氨酸/肌酐 (NAA/Cr) 比率。 现象学将通过结构化诊断访谈进行评估， 临床医生评定量表和患者评定问卷。我们假设 (1) 基线时已患有 BD 的高危后代将具有不同的 激活和失活比健康对照，主要是在 DLPFC 和 前扣带皮层 (ACC)，(2) 患有 BD 的高危后代将具有较低的 与健康对照相比，双侧 DLPFC 中的 NAA/Cr 比率，以及 (3) 有风险 在本研究过程中患上 BD 的后代将表现出更大的 与对照组和大脑模式相比，DLPFC NAA/Cr 较基线降低 激活类似于那些已经患有 BD 的受试者，无论是在基线还是在 三年随访。通过开展本研究项目并 实施研究培训计划，张博士计划成为一名 儿科 BD 领域的独立研究者，从而为 神经生物学和 BD 发展的最新知识。