Neural Patterns of Visual Learning in Schizophrenia

精神分裂症视觉学习的神经模式

• 批准号: 6920937
• 负责人: NICOLA G CASCELLA
• 金额: $ 6.25万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-20 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6920937
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; functional magnetic resonance imaging; human subject; learning; mental disorder diagnosis; neural information processing; patient oriented research; schizophrenia; visual feedback; visual stimulus

DESCRIPTION (provided by applicant): Schizophrenia is an illness with multiple symptom manifestations that cluster into at 3 domains: (1) reality distortion (hallucinations and delusions), (2) negative symptoms (psychomotor retardation), and (3) disorganization (thought disorder). We have previously associated distinctive rCBF patterns with positive and negative symptom domains, supporting the idea of rCBF differences across symptom subtypes. In addition to symptoms, persons with schizophrenia show inadequate neuropsychological performance when evaluated on test of intelligence, memory, attention, and executive function. Blood oxygen level dependent contrast (BOLD) analysis using fMRI, focused on questions of integrative neurobiology in schizophrenia subtypes (particular symptom groups), brings a contemporary research technique to bear on a complex clinical brain/behavior disorder. We will assess performance improvement on a visual DMST with feedback in 15 schizophrenic patients with primary enduring negative symptoms (Deficit Schizophrenia or DS) and 15 schizophrenic patients with predominant hallucinations and delusions (Reality Distortion or RD). We predict that schizophrenic volunteers will show learning but that the deficit group will fail to improve as much as the RD group because the deficit volunteers will not be able to use feedback to enhance their learning. Using BOLD signal changes we will define the neural activity patterns in DS and RD volunteers during learning of the visual DMST. The RD will exhibit a significant increase in the anterior cingulate hemodynamic response after perceptual training. DS volunteers will exhibit a significantly reduced BOLD response in the inferior parietal lobe before and after training. Enduring primary negative symptoms are also expected to prevent feedback-dependent changes in the cingulate cortex.

描述（由申请人提供）：精神分裂症是一种患有多种症状表现的疾病，它们聚集在3个领域中：（1）现实失真（幻觉和妄想），（2）负面症状（心理运动迟缓）和（3）混乱（思想障碍）。我们以前已经将独特的RCBF模式与正症状域和负面症状结构域相关联，从而支持症状亚型的RCBF差异的想法。除症状外，精神分裂症患者在评估智力，记忆，注意力和执行功能的测试时，神经心理学表现不足。使用fMRI的血氧水平依赖性对比度（BOLD）分析，重点介绍了精神分裂症亚型（特定症状组）中综合神经生物学问题（特定症状组），带来了一种当代研究技术，以涉及复杂的临床大脑/行为障碍。我们将评估15例主要持久症状（缺陷精神分裂症或DS）和15名具有主要幻觉和妄想（现实失真或RD）的精神分裂症患者的精神分裂症患者（现实扭曲或RD）的15例精神分裂症患者的反馈。我们预测，精神分裂症志愿者将显示学习，但是赤字小组将无法像RD组一样改善，因为赤字志愿者将无法使用反馈来增强他们的学习。使用大胆的信号变化，我们将在学习视觉DMST期间定义DS和RD志愿者中的神经活动模式。感知训练后，RD将显着增加前扣带回血液动力学反应。 DS志愿者将在训练前后的下顶叶中表现出明显减少的大胆反应。持久的原发性负面症状也有望防止扣带回皮层的反馈依赖性变化。