"Beyond Cancer":Fostering transitions post-treatment

“超越癌症”：促进治疗后的转变

• 批准号: 7126241
• 负责人: KATHLEEN A. DWYER
• 金额: $ 7.27万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126241
• 关键词: Hodgkin' s disease; behavioral /social science research tag; caregivers; clinical research; clinical trials; cognitive behavior therapy; colorectal neoplasms; focus groups; functional ability; gender difference; human subject; human therapy evaluation; interview; longitudinal human study; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer immunotherapy; neoplasm /cancer invasiveness; nonHodgkin' s lymphoma; outcomes research; psychological adaptation; psychological aspect of cancer; quality of life; questionnaires; social support network; socioenvironment; videotape /videodisc

DESCRIPTION (provided by applicant): The relative 5-year survival rate for all cancer sites has increased over the past 20 years. More patients are completing treatment and entering the early post-treatment phase of coping with their illness. The end of treatment phase may be emotionally and physically crippling. These issues are typically not recognized and addressed by health care providers, and therefore, there are long-term survivors who never resume a 'normal' life. Most existing interventions use a face-to-face format, thus limiting their use to individuals who have the ability to 'get to' the intervention site. The proposed two-stage pilot study seeks to modify and then evaluate the acceptability and feasibility of the modified intervention strategy designed to enhance the return to a productive existence and improve quality of life. The proposed study addresses the previously identified gaps and limitations by: studying men and women cancer patients using two tumors that are gender neutral; incorporating the patient's and caregiver's perspectives; controlling for potential gender differences by blocking on gender; delivering the intervention during the first 3 months post-treatment; and using a format that makes the intervention widely accessible [videotapes, a manual, telephone conference calls]. In particular, this proposal addresses the following questions: (1) How does an existing cognitive behavioral intervention program need to be adapted for use during the first 3 months following treatment with patients completing treatment for colorectal cancer, Hodgkin's disease, or Non-Hodgkin's lymphoma and their primary caregivers?; (2) How acceptable is the modified cognitive behavioral intervention program to patients and caregivers during the first 3 months after completing treatment?; and (3) What effects does the intervention have on the perceived control, coping, perceived social support, and quality of life reported by the participants? How sizable are the effects? In the first stage, we will conduct a descriptive study to elicit feedback about the existing intervention. Participants will be given the existing intervention videotapes and workbook along with evaluation questions. After reviewing the materials, a focus group to elicit specific feedback will be conducted. For Stage Two, a randomized clinical trial will be conducted to evaluate the acceptability/feasibility of the modified intervention as well as to determine the effects on quality of life and other related outcomes.

描述（由申请人提供）：在过去20年中，所有癌症部位的相对5年生存率都有所提高。越来越多的患者正在完成治疗，并进入应对疾病的早期治疗阶段。治疗阶段的结束可能在情感和身体上都很残酷。这些问题通常不会被医疗保健提供者认可和解决，因此，有一些长期幸存者从不恢复“正常”生活。大多数现有的干预措施都采用面对面的格式，从而将其使用限制在有能力“进入”干预站点的个人中。拟议的两阶段试点研究旨在修改，然后评估旨在增强富有生产力并改善生活质量的改良干预策略的可接受性和可行性。拟议的研究通过以下方式解决了先前确定的差距和局限性：使用两种性别中性肿瘤研究男性和女性癌症患者；结合患者和照料者的观点；通过阻止性别来控制潜在的性别差异；在治疗后的头三个月内进行干预；并使用使干预措施广泛访问的格式[录像带，手册，电话会议]。特别是，该提案解决了以下问题：（1）在治疗治疗后三个月内，现有的认知行为干预计划如何用于完成结直肠癌，霍奇金病或非霍奇金淋巴瘤及其主要护理人员的治疗？ （2）在完成治疗后的头三个月中，改良的认知行为干预计划如何接受？ （3）干预对参与者报告的感知，应对，感知的社会支持以及生活质量的感知控制，应对，感知的社会支持和生活质量有何影响？效果如何？在第一阶段，我们将进行一项描述性研究，以引起有关现有干预措施的反馈。参与者将获得现有的干预录像带和工作簿以及评估问题。审查了材料后，将进行一个焦点小组，以引起特定的反馈。对于第二阶段，将进行一项随机临床试验，以评估修改后的干预措施的可接受性/可行性，并确定对生活质量和其他相关结果的影响。