Psychosocial Impact of Cancer-Related Female Infertility

癌症相关女性不孕症的心理社会影响

• 批准号: 6929902
• 负责人: Andrea Lynn Canada
• 金额: $ 2.55万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6929902
• 关键词: Hodgkin' s disease; behavioral /social science research tag; breast neoplasms; cervix neoplasms; child rearing; clinical research; emotions; family structure /dynamics; female; fertility; human subject; interview; neoplasm /cancer genetics; nonHodgkin' s lymphoma; pregnancy; psychological aspect of cancer; psychological stressor; psychometrics; quality of life; questionnaires; stress

DESCRIPTION (provided by applicant): Cancer frequently disrupts women's ability to have children because of treatment-related infertility, concern about health risks during pregnancy, and/or fear of having a child with a birth defect or high lifetime risk of cancer. Little is known about the impact of disrupted childbearing on survivors' emotional well-being or quality of life. Infertile women who have not had cancer, however, suffer long-term consequences of anxiety and depression after failed attempts at pregnancy or adoption. We will survey 2,091 women from the UT M. D. Anderson Cancer Center tumor registry, diagnosed before the age of 40, during the years 1992 to 1997, with either breast cancer, invasive cervical cancer, Hodgkin's disease, or non-Hodgkin's lymphoma. Women will be contacted by letter and then by phone to invite participation. We expect at least a 50 percent response rate. Participants will complete a brief set of written questionnaires, taking about 20 minutes, and after they have mailed these back, will be interviewed by phone for about 60 minutes with a semi-structured protocol about their reproductive history after cancer, including attitudes and emotions. Both genetic and social parenthood will be explored. Outcome measures include health-related quality of life (SF-12), emotional distress (BSI-18), stress response related to cancer and childbearing (Impact of Event Scale), and a new scale that measures anxiety related to cancer and childbearing issues. Based on the model that cancer followed by interrupted childbearing is a repeated trauma, causing long-term distress, we have the following specific hypotheses: 1) Women whose cancer interfered with desired childbearing will have significantly more general distress and infertility-specific distress, and poorer quality of life than women who had already completed their families before diagnosis. 2) Within the group who wanted children at diagnosis, breast cancer survivors will be more distressed than others because of their added concerns about hormonal stimulation of cancer recurrence and inherited cancer syndromes. 3) Within the group that wanted children after cancer, those who achieve genetic parenthood will be the least distressed, followed by those who become social parents (donated egg, adoption, stepchildren), and the most distressed will be those who have no children after cancer, particularly those childless at diagnosis. We plan to use these data to create an intervention to reduce distress and provide information to women whose childbearing is interrupted by cancer.

描述（由申请人提供）： 癌症经常破坏妇女由于与治疗相关的不孕症，怀孕期间的健康风险的关注以及/或担心患有出生缺陷或癌症终身较高的终身风险的害怕。关于破坏生物对幸存者情感健康或生活质量的影响知之甚少。然而，在怀孕或收养尝试失败后，尚未患有癌症的不育妇女遭受了焦虑和抑郁的长期后果。我们将在1992年至1997年期间诊断出40岁以前的UT M. D. Anderson癌症中心肿瘤注册中的2,091名女性，其中包括乳腺癌，侵入性宫颈癌，霍奇金病或非霍奇金淋巴瘤。将通过信件与妇女联系，然后通过电话与妇女联系以邀请参与。我们预计至少有50％的回应率。参与者将完成一系列简短的书面问卷，大约需要20分钟，然后通过电话邮寄这些问卷，并通过电话进行大约60分钟的采访，并使用半结构化的协议，内容涉及其癌症后的生殖历史，包括态度和情感。遗传和社会育儿都将被探讨。结果指标包括与健康相关的生活质量（SF-12），情绪困扰（BSI-18），与癌症和生育有关的压力反应（事件量表的影响）以及与癌症和生育问题有关的焦虑的新量表。基于癌症又是育儿中断的模型，是一种反复的创伤，造成长期困扰，我们有以下特定的假设：1）癌症干扰所需的生育的妇女比已经在诊断之前已经完成家人的妇女更具普遍的困扰和不育特异性的困扰和较差的生活质量。 2）在想要诊断儿童的小组中，乳腺癌幸存者会比其他人更加痛苦，因为他们对癌症复发和遗传性癌症综合症的激素刺激的额外担忧。 3）在癌症后想要儿童的小组中，那些获得遗传父母的人将是最小的痛苦，其次是那些成为社会父母的人（捐赠鸡蛋，收养，继子女），最痛苦的人将是那些没有癌症后没有孩子的人，尤其是那些在诊断中没有孩子的人。我们计划使用这些数据来创建一种干预措施，以减少困扰并向癌症中断生育的妇女提供信息。