A Novel Post-Menopausal Osteoporosis Screening Tool

一种新型绝经后骨质疏松症筛查工具

• 批准号: 6952678
• 负责人: AMIT BHATTACHARYA
• 金额: $ 7.65万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-25 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952678
• 关键词: biomechanics; bone density; bone fracture; clinical research; diagnosis design /evaluation; female; human old age (65+); human subject; mass screening; mechanical stress; musculoskeletal disorder diagnosis; musculoskeletal imaging /visualization /scanning; noninvasive diagnosis; osteoporosis; patient oriented research; photon absorptiometry; postmenopause; questionnaires; women' s health

DESCRIPTION (provided by applicant): Osteoporosis has a significant impact on the United States population, with more than 25 million people affected by the disease. Often times, this predisposed degenerative disease leads to about 1.3 million fractures per year with the costs being in excess of 10 billion dollars. This revised grant application will develop and evaluate a novel and yet economical technique, which has the potential to be used as a non-invasive and objective tool for detecting indications of spine fractures in post-menopausal osteoporotic women. The proposed non-invasive technique can provide critical information about the quality of the bone that can supplement traditional DEXA bone mineral density (BMD) measurements. The post-menopausal osteoporosis technique will utilize miniature skin mounted accelerometers to capture the changes in effective damping capacities and other mechanical properties (including brittleness) of natural shock absorbers of the human musculoskeletal systems (soft tissues including muscles and trabecular bone which has significant elastic capacity in healthy bones), associated with heel strike induced force propagation. The literature lacks information regarding how osteoporosis affects natural shock absorbers. The potential of success for the proposed technique's ability to capture shock absorption properties of osteoporotic bones is high since preliminary studies from our group have successfully quantitated natural shock absorbers of the musculoskeletal system in another type of degenerative musculoskeletal diseases i.e. osteoarthritic patients. The proposed technique is totally non-invasive, objective, simple and quick to administer. The proposed study will focus on measuring natural shock absorption properties of postmenopausal osteoporosis with and without fractures and supplement information gathered from BMD measurements. Once the proposed technique shows promise future prospective study will allow determination of the effectiveness of the technique to diagnose individuals at risk for fracture, pre-clinically.

描述（由申请人提供）： 骨质疏松症对美国人口造成重大影响，超过 2500 万人受到该疾病的影响。通常，这种易诱发的退行性疾病每年会导致约 130 万例骨折，造成的费用超过 100 亿美元。这项修订后的拨款申请将开发和评估一种新颖且经济的技术，该技术有潜力用作非侵入性客观工具，用于检测绝经后骨质疏松女性脊柱骨折的迹象。所提出的非侵入性技术可以提供有关骨骼质量的关键信息，从而补充传统的 DEXA 骨矿物质密度 (BMD) 测量。绝经后骨质疏松症技术将利用微型皮肤安装加速度计来捕捉人体肌肉骨骼系统（包括具有显着弹性能力的肌肉和骨小梁等软组织）的有效阻尼能力和其他机械性能（包括脆性）的变化在健康的骨骼中），与脚跟着地引起的力传播有关。 文献缺乏有关骨质疏松症如何影响天然减震器的信息。由于我们小组的初步研究已经成功定量了另一种退行性肌肉骨骼疾病（即骨关节炎患者）中肌肉骨骼系统的天然减震器，因此所提出的技术捕获骨质疏松骨骼的减震特性的成功潜力很高。 所提出的技术是完全非侵入性的、客观的、简单且易于管理的。拟议的研究将重点测量有或没有骨折的绝经后骨质疏松症的自然减震特性，并补充从 BMD 测量中收集的信息。一旦所提出的技术显示出希望，未来的前瞻性研究将能够确定该技术在临床前诊断有骨折风险的个体的有效性。