Early Pb exposure a risk for bone health later in life in African American women

早期接触铅对非裔美国女性晚年骨骼健康构成风险

• 批准号: 9036387
• 负责人: AMIT BHATTACHARYA
• 金额: $ 58.22万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-09 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9036387
• 关键词: Address; Adult; Affect; African American; Age; Biological; Birth; Blood specimen; Body Burden; Bone Density; Bone Growth; Bone Mineral Contents; Caucasians; Childhood; Chondrocytes; Cohort Studies; Data; Development; Diagnosis; Dietary Calcium; Epiphysial cartilage; Equilibrium; Fracture; Gasoline; General Population; Geometry; Health; Hip region structure; Hormonal; Injury; Knowledge; Lactose; Lead; Lead levels; Life; Literature; Low Birth Weight Infant; Measurement; Measures; Methods; Minority; Minority Groups; Muscle; Musculoskeletal Equilibrium; Nutritional status; Organ; Osteoporosis; Outcome; Population; Predisposition; Process; Prospective Studies; Public Health; Recording of previous events; Research; Resistance; Resources; Risk; Role; Shock; Signal Pathway; Skeleton; Source; System; Techniques; Time; Venipunctures; Vertebral column; Vitamin D; Weight-Bearing state; Woman; absorption; base; blood Pb concentration; bone; bone health; bone mass; cohort; design; early life exposure; environmental Pb exposure; experience; fall risk; falls; gender disparity; innovation; interest; lead concentration; lead exposure; meetings; postnatal; racial disparity; sound; tibia; tool

DESCRIPTION (provided by applicant): The proposed study is designed to provide transformative knowledge for the first time, about how childhood history of environmental lead (Pb) exposure impacts combined bone and musculature (CBAM) health later in life among African American women. While blood lead concentrations (PbB) in the general population of the U.S. have declined since the discontinuation of Pb as a gasoline additive, Pb sequestered in bone continues to be a source of internal exposure for millions of women, especially minorities exposed to moderate to high levels of Pb during their formative years. African-American women have lower dietary calcium, more likely to be lactose intolerant, vitamin D deficient and have environmental Pb exposure that is associated with lower birth weight, poor postural balance and falls. Therefore, combined risks of nutritional status and Pb exposure potentially compromise several bone and muscular parameters. These include bone mineral content (BMC), bone mineral density (BMD), lower birth weight affecting postnatal bone growth and structural integrity of CBAM. Lower structural integrity suggests reduced ability of CBAM to absorb externally applied dynamic loads thereby increasing susceptibility to bone fracture. The energy absorption or damping (ζ) ability of the CBAM system is measured with a non-invasive, bone shock absorption (BSA) tool recently developed by our group. These Pb associated detrimental changes in bone and muscular parameters could collectively predispose to development of early osteoporosis associated susceptibility to fracture than those with no or lower Pb exposure. Furthermore, Pb affects osteoclastic and osteoblastic processes, hormonal signaling pathways, and the rate of growth plate chondrocyte maturation and contributes to functional postural instability (FPS) as an added risk for fall related fractures and injuries. These studies form the basis for our long-term core hypothesis: "early life exposure to Pb detrimentally affects bone health as characterized by bone mass, macrostructure of the skeleton, and CBAM's structural integrity ability to sustain dynamic load, as well as postural stability/balance thereby predisposing the subjects to increased fracture risk later in life". The proposed study will be carried out with our existing Cincinnati Lead Study (CLS) cohort; thus allowing us to leverage the extensive data resources of our CLS prospective study which has experienced moderate to high levels of Pb exposure during their early life (late1970s and 1980's) and is now approaching bone maturation age (28-32 years).The first step towards addressing the long term core hypothesis is to evaluate the abilities of the proposed measures of bone's macrostructure, BMD, FPS and ζ, collectively and individually for identifying Pb exposed subjects who meet or approach the independent thresholds from the literature for falls, and osteoporosis associated fracture and no fracture as well as from healthy subjects within the CLS age range.

描述（由适用提供）：拟议的研究旨在首次提供变革性的知识，关于环境铅的童年历史（PB）暴露量如何影响骨骼和肌肉组织（CBAM）在非洲裔美国妇女的后期生活。自从PB以汽油添加剂为中止以来，美国普通人群的血液铅浓度（PBB）下降了，但在骨骼中隔离的PB仍然是数百万妇女的内部暴露源，尤其是少数族裔，尤其是在其形成年期间暴露于中度至高水平的PB。非裔美国妇女的饮食钙较低，更有可能是乳糖不耐症，维生素D缺乏，并且具有与出生体重较低，姿势平衡和下降相关的环境PB暴露。因此，营养状况和PB暴露的综合风险可能会损害几个骨头和肌肉参数。其中包括骨矿物质含量（BMC），骨矿物质密度（BMD），影响产后骨骼生长和CBAM结构完整性的较低的出生体重。较低的结构完整性表明，CBAM吸收外部施加动态载荷的能力降低，从而增加了对骨折的敏感性。 CBAM系统的能量吸收或阻尼能力是通过我们组最近开发的非侵入性骨休克吸收（BSA）工具来测量的。与没有或较低PB暴露的PB相关的PB相关的有害变化可能会倾向于倾向于发展早期骨质疏松症的易感性。此外，PB会影响整骨和成骨细胞过程，马式信号通路以及生长板的速率软骨细胞的成熟速率，并有助于功能性姿势不稳定（FPS），这是对跌倒相关骨折和损伤的增加的风险。这些研究构成了我们的长期核心假设的基础：“早期生命暴露于PB的早期暴露于骨骼质量，骨架的宏观结构以及CBAM的结构完整性能力，以维持动态载荷的能力，以及姿势稳定性/平衡，从而使受试者在生命后期增加了交易风险。”拟议的研究将与我们现有的辛辛那提铅研究（CLS）队列一起进行；因此，让我们能够利用CLS前瞻性研究的广泛数据资源，该研究在早期（1970年代和1980年代末）经历了中等至高水平的PB暴露，现在正在接近骨骼成熟年龄（28-32岁）。长期核心假设是评估核心概述的核心量度和bone bone bone bone bont bone and bonk bortermiper的第一步。鉴定出与文献相遇或接近独立阈值的PB暴露受试者，以及骨质疏松症相关的骨折，无骨折以及CLS年龄范围内的健康受试者。