CORE--BIOSTATISTICS AND COMPUTATIONAL BIOLOGY

核心--生物统计学和计算生物学

• 批准号: 6936117
• 负责人: Thomas B Kepler
• 金额: $ 22.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936117
• 关键词: AIDS; HIV infections; bioinformatics; biomedical facility; computational biology; data collection methodology /evaluation; experimental designs; human data; immune response; mathematical model; nucleic acid sequence; patient /disease registry; protein sequence; statistics /biometry

DESCRIPTION (provided by applicant): The primary responsibilities of the Biostatistics and Computational Biology (BCB) research team will be to participate in the CFAR research effort by supplying experimental design and data-analytical consulting during the developmental stages of new projects and in the preparation of grant proposals and to work with investigators on innovative approaches to informatics and mathematical/statistical modeling. The areas supported will include clinical biostatistics and computational biology, including gene expression and all aspects of nucleic acid and protein sequence analysis. In collaboration with Duke University Laboratory of Computational Immunology, the BCB core will also support methodological development and mathematical modeling of viral and immune dynamics. There will be two modes of interaction with the CFAR investigators. Under the first, new innovative projects will be treated as collaborative endeavors with no charge-back to the client. The expectation is that compensation will accrue to the BCB as collaborators on grants and contracts arising from this new work. Furthermore, the BCB may gain the opportunity to submit applications for related methodological work. Under the second model, ongoing projects with funding for statistical and/or computational biological work as well as industry-sponsored projects can contract with the BCB on a for-fee basis. The BCB core is devoted to the establishment and maintenance of easy communication with the CFAR investigators and the other cores. The BCB director, Dr. Thomas B. Kepler, has expertise in immunology (and a secondary appointment in the Duke Department of Immunology) as well as computational biology and statistics, which are his primary research fields. The core group will be trained to understand the science and medicine and the language in which they are expressed.

描述（由申请人提供）：生物统计学的主要职责和 计算生物学（BCB）研究小组将参加CFAR研究工作 在新项目的发展阶段以及准备赠款建议的过程中，提供实验设计和数据分析咨询，并与调查人员进行有关信息学和数学/统计建模的创新方法的合作。所支持的区域将包括临床生物统计学和计算生物学，包括基因表达以及核酸和蛋白质序列分析的所有方面。与杜克大学计算免疫学实验室合作，BCB核心还将支持病毒和免疫动力学的方法论发展和数学建模。与CFAR研究人员将有两种互动模式。首先，新的创新项目将被视为协作努力，而对客户无需退款。期望薪酬将为BCB作为赠款和合同的合作者而引起的薪酬。此外，BCB可能会有机会提交相关方法学工作的申请。在第二个模型下，正在进行的统计和/或计算生物学工作以及行业赞助的项目的持续项目可以收缩 与BCB开展的基础。 BCB核心致力于与CFAR调查人员和其他核心进行易于沟通的建立和维护。 BCB主管Thomas B. Kepler博士在免疫学（以及杜克大学免疫学系的次要任命）以及计算生物学和统计学方面具有专业知识，这是他的主要研究领域。核心小组将接受培训，以了解科学和医学及其表达的语言。