Modeling Immunity for Biodefense

生物防御免疫建模

• 批准号: 7952360
• 负责人: Thomas B Kepler
• 金额: $ 205.81万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952360
• 关键词: Modeling; Immunity; Biodefense

The program, Modeling Immunity for Biodefense, will develop novel or improved highly predictive mathematical models that simulate immune function. These model systems will be developed for analysis of host immune responses to NIAID category A-C pathogens, and may apply to other infectious and immune-mediated diseases. Knowledge gained from these studies will: advance our understanding of the delicate balance required to induce protective immunity; guide laboratory experiments of host immune responses; and lay the foundation for development of models that can extrapolate human immune responses to infection or immune-mediated diseases based on results from relevant in vitro and in vivo studies. This contract includes studies on bacillus anthracis.

该程序对生物陷入困境进行建模的免疫力将开发出新颖或改进的高度预测性数学模型，以模拟免疫功能。这些模型系统将开发用于分析宿主对NIAID类别A-C病原体的免疫反应，并可能适用于其他感染和免疫介导的疾病。从这些研究中获得的知识将：促进我们对诱导保护性免疫所需的微妙平衡的理解；指导宿主免疫反应的实验室实验；并奠定了可以根据体外和体内研究的结果推断人免疫反应或免疫介导的疾病的模型的基础。 该合同包括对炭疽芽孢杆菌的研究。