BODY COMPOSITION: METHODS, MODEL & CLINICAL APPLICATION

身体成分：方法、模型

• 批准号: 6796483
• 负责人: Steven B Heymsfield
• 金额: $ 6.34万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-12 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796483
• 关键词: body composition; body physical characteristic; method development; morphometry

This proposal ties together four projects and three core laboratories that collectively share the hypothesis that application of advanced, or creation of new, body composition measurement methods will provide new and clinically important biological insights. The third in this series of Program Project Grants, the present PPG builds upon the success of PPG II with over 700 subject cross-sectional and 500 longitudinal evaluations using state-of-the art measurement methods, four new or improved facilities, four new or improved facilities within the core units (i.e., new in vivo Neutron Activation Analysis (IVNA), Magnetic Resonance Imaging (MRI) Analysis, Bioimpedance Analysis, and Regional 40K Counter; upgrade delayed-gamma, prompt-gamma, and inelastic scattering neutron activation systems), advanced method development (gamma nuclear resonance absorptiometry), important insights into the aging process, HIV-related conditions and obesity, and over 150 published original reports and reviews. The third phase of the PPG is formulated on the interactive projects that are focused on: 1. Advanced skeletal muscle method and method development with a focus on children, adolescents, and adults either gaining or losing body weight; 2. The newly reported HIV-lipodystrophy syndrome and its relationship to phenotypically similar subjects without viral illnesses, both before and after interventions designed to alter metabolic status; 3. The bone and skeletal muscle effects of gastric obesity surgery in type II diabetic subjects with BMI >35 less than or equal too 40 kg/m2 compared to those observed in medically-managed comparable patients; and 4. The lowering of resting energy expenditure observed with aging, even after controlling for conventional body composition measures. The projects will be linked and interact with two continued cores (A, Columbia, Laboratories, and B, Brookhaven National Laboratory) and a new core (C, Biostatistics and Data Management) emerging to fully utilize the PPG's expanding database and to chart new areas of interest including body composition and image modeling. A close tie with Columbia's new Department of Biomedical Engineering will be developed with planning imaging and nuclear studies combined with use of the Medical School's high-field strength Hatch MRI and positron emission facilities. The large number of developing and planned interactions extend the program's boundaries outside of the four- hypothesis driven projects. This PPG aims to broadly extend clinical and research capabilities for measuring body compartments to answer important and prevailing clinical questions and to bridge the expanding interface between biology and engineering.

该提议将四个项目和三个核心实验室联系在一起，这些项目共同分享了以下假设：高级或创建新的，身体组成的测量方法的应用将提供新的和临床上重要的生物学见解。本系列项目项目中的第三个授予，目前的PPG建立在PPG II的成功基础上，使用了700多个主题横截面和500次使用最先进的测量方法，四个新的或改进的设施，四个新的或改进的设施，核心单位中的四个新或改进的设施（即新的或改进的设施）区域40K计数器；升级伽玛，及时伽玛和非弹性散射中子激活系统，高级方法开发（伽马核共振吸收仪），对衰老过程，与HIV相关的条件和肥胖症的重要见解以及超过150个发表的原始报告和评论。 PPG的第三阶段是在关注：1。高级骨骼肌方法和方法开发的交互式项目上制定的，重点是儿童，青少年和成年人增加体重或失去体重； 2。新报告的HIV-脂肪营养不良综合征及其与旨在改变代谢状况的干预措施之前和之后与具有病毒疾病的表型相似受试者的关系； 3。与在医学管理的可比较患者中观察到的胃肥胖手术的骨骼和骨骼肌作用低于或相等40 kg/m2，胃肥胖手术的骨骼和骨骼肌作用少于或相等40 kg/m2。和4。即使在控制常规的身体组成措施之后，观察到的静息能量消耗也会降低。这些项目将与两个持续的核心（A，哥伦比亚，实验室和B，Brookhaven国家实验室）和一个新的核心（C，Biostatistics和数据管理）联系起来，并与PPG的扩展数据库充分利用新的核心，并列出了新的兴趣领域，包括身体成分和图像模型。将与哥伦比亚新​​的生物医学工程系紧密联系，并通过计划成像和核研究以及使用医学院的高场强度孵化MRI和正电子排放设施的方式开发。大量的发展和计划的互动将计划的边界扩展到四个假设驱动的项目之外。该PPG旨在广泛地扩展临床和研究能力，以测量身体隔室，以回答重要和流行的临床问题，并弥合生物学和工程之间的扩展界面。