CORE--NEUTRON ACTIVATION FACILITY

核心——中子活化装置

• 批准号: 6653322
• 负责人: F A DILMANIAN
• 金额: $ 14.86万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6653322
• 关键词: activation analysis; analytical method; biomedical facility; biotechnology; body composition; body physical characteristic; clinical research; computer system design /evaluation; human subject; mathematical model; morphometry; photon absorptiometry; technology /technique development

Core Unit B will provide Program Project Grant (PPG) investigators with three services: high precision whole-body in vivo neutron activation (IVNA) analysis measurements of H, C, N, O, Ca, P, Na, and C1, and whole-body counting for K; expert assistance with interpretation and analysis of IVNA results; and physics consultations for new instrument design and development. Instrumentation for high precision measurements of body composition by IVNA were developed and equipped with state-of-the-art hardware during PPG I. Subsequent improvements in the analytical strategies extended the range of subjects that were included in the studies during PPG II measurement precisions of the IVNA facilities were further improved using new and improved phantoms and by implementing a Monte Carlo code (MCNP) to carry out extensive simulations for different body configurations and stature. During this period extensive calibrations and cross-calibrations with investigators at Baylor for Ca and with investigators at Core Unit A for total body potassium (TBK), were carried out with publication of results. Replacement of older computers with newer systems enabled transfer from an early software environment to contemporary operating systems. These improvements along with basic operations upgrades allowed measurement routinely of up to six patients per week with stabilized systems. Core support during the proposed PPG III for clinical research projects will continue and important new initiatives will be instituted, including: new calibrations for measuring TBK and Ca in obese patients in Project 3; correlation of partial/regional body nitrogen to total body nitrogen with Core A; creation of independent MCNP input files that describe the human body as simulated by a BOMAB phantom for each of the three activation facilities; and design of a Gamma Nuclear Resonance Absorptiometry system for elemental imaging in vivo. The Core's activities are consistent with the Department of Energy's mandate to develop novel technologies, to transfer these systems to cooperating laboratories following their developing and testing phase, and to maintain state-of-the art systems for use as national and internal reference standards.

核心单元B将为计划项目赠款（PPG）研究人员提供三种服务：高精度全身中性中子激活（IVNA）分析测量测量H，C，C，N，O，CA，P，NA和C1，以及K的全身计数；在解释和分析IVNA结果方面的专家协助；以及有关新仪器设计和开发的物理咨询。开发并配备了PPG I.在PPG I.中开发并配备高精度测量的仪器，并配备了最先进的硬件I.随后改进了分析策略的改进，扩大了PPG II测量精度中所包含的受试者的范围，用于使用新的和改进的IVNA的范围来进一步改进范围，以进一步提高范围的范围，以实施新的和改进的MONTE CARLOS（MCN）（MCN）（MCN）（MCN）（MCN）（MCN）（MCN）身材。在此期间，通过出版结果进行了广泛的校准和与研究人员的CA和Core A核心A的研究人员进行的跨校准。用较新的系统替换较旧的计算机启用了从早期的软件环境转移到现代操作系统。这些改进以及基本操作升级允许每周最多六名患者使用稳定系统测量。在拟议的PPG III期间，将继续进行临床研究项目的核心支持，并将制定重要的新计划，包括：在项目3中测量肥胖患者的TBK和CA的新校准；部分/区域身体氮与总体氮与核心A的相关性；创建独立的MCNP输入文件，这些文件将人体描述为由Bomab Phantom模拟的三个激活设施中的每个模拟；以及用于体内元素成像的伽马核共振吸收率系统的设计。核心的活动与能源部开发新技术的任务是一致的，将这些系统转移到其开发和测试阶段之后的实验室合作，并维护最先进的系统，以用作国家和内部参考标准。