MRI Visceral Adipose Tissue Partitioning:Advanced Models

MRI 内脏脂肪组织分区：高级模型

• 批准号: 6720003
• 负责人: Steven B Heymsfield
• 金额: $ 16.14万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-19 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6720003
• 关键词: adipose tissue; age difference; bioimaging /biomedical imaging; body composition; clinical research; comorbidity; computed axial tomography; data management; gender difference; human data; information systems; magnetic resonance imaging; metabolism; obesity; phenotype; racial /ethnic difference; whole body imaging /scanning

DESCRIPTION (provided by applicant): Excessive adiposity is emerging as the nation's most significant health problem. Although total body adipose tissue (AT) accounts for more than one-fourth of body mass in the average American adult, only certain relatively small highly active compartments are strongly associated with morbidity. The most widely studied of these is visceral adipose tissue (VAT). Measuring VAT is currently central to phenotyping human subjects for obesity and the accepted reference measurement methods are magnetic resonance imaging (MRI) and computed tomography (CT). CT is of limited applicability due to radiation exposure. The traditional imaging approach for quantifying VAT is to measure the cross-sectional VAT "area" at the level of the L4-L5 vertebrae using CT or MRI. The L4-L5 level is an anatomic location established largely by convenience as representative of total VAT. An extensive recent review completed by our group reveals large discrepancies across studies in VAT measurement by imaging methods. This lack of consensus is troubling in view of the critical need for improved phenotyping and for monitoring small but metabolically significant effects of interventions on important adipose tissue compartments. Recent studies suggest that intraperitoneal AT, mainly omental and mesenteric AT, is the VAT component that most strongly links adiposity with adverse biological outcomes and morbidity. Intraperitoneal AT is not localized mainly at L4-L5, but at higher levels, and we have preliminary data suggesting other anatomic locations may be more strongly related to undesirable levels of metabolic measures. Moreover, total VAT includes multiple AT components and may not be the best marker of intraperitoneal AT or outcomes. To investigate these questions we propose to assemble and analyze the largest-to-date (~3000 scans) and most subject-diverse whole-body MRI database linked to associated body composition and laboratory studies. The pooled images and data will provide the needed initial data and rationale for expanding MRI studies into the emerging area of high-resolution image acquisition. It will also permit testing many other important hypotheses related to methods, model development and biological interests. Our findings could help to set new standards for VAT and adipose tissue subcompartment measurement, lower the cost of MRI body composition studies, and improve study power.

描述（由申请人提供）：过度肥胖已成为美国最重大的健康问题。尽管总体脂肪组织（AT）在普通成年人中占体重的四分之一以上，但只有某些相对较小的高度活性室与发病率密切相关。其中最广泛的研究是内脏脂肪组织（VAT）。目前，测量增值税对于肥胖症的表型人类受试者目前是核心，所接受的参考测量方法是磁共振成像（MRI）和计算机断层扫描（CT）。由于辐射暴露，CT的适用性有限。量化增值税的传统成像方法是使用CT或MRI测量L4-L5椎骨水平的横截面“区域”。 L4-L5水平是一个解剖位置，在很大程度上以方便起见为代表总增值税。我们小组完成的最新审查揭示了通过成像方法在增值税测量中进行的大量研究。鉴于对改善表型的至关重要的需求以及监测干预措施对重要脂肪组织隔室的重要影响，这种缺乏共识令人不安。最近的研究表明，腹膜内主要是膜和肠系膜AT，是增值税成分，最强烈地将肥胖与不良生物学结局和发病率联系起来。腹膜内的AT不是主要位于L4-L5，而是在较高的水平上，我们有初步数据表明其他解剖位置可能与不良的代谢措施水平更密切相关。此外，总增值税包括多个组件，并且可能不是腹膜内或结果的最佳标记。为了调查这些问题，我们建议组装和分析与相关的身体组成和实验室研究相关的最大到日期（〜3000张扫描）和大多数主题的全身MRI数据库。合并的图像和数据将提供所需的初始数据和基本原理，以将MRI研究扩展到高分辨率图像采集的新兴领域。它还将允许测试与方法，模型开发和生物学兴趣有关的许多其他重要假设。我们的发现可能有助于为增值税和脂肪组织子组门的测量设定新标准，降低MRI身体组成研究的成本并提高研究能力。