Evolution of Duplicate Genes at the Genomic Level

基因组水平上重复基因的进化

基本信息

批准号：
6929295
负责人：
WEN-HSIUNG LI
金额：
$ 17.42万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-08-01 至 2006-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6929295
关键词：
computer program /software computer system design /evaluation eukaryote evolution gene duplication gene expression gene frequency genome mathematical model microarray technology statistics /biometry

项目摘要

DESCRIPTION (provided by applicant): Our goal is to understand the process and mechanisms of the evolution of duplicate genes in eukaryotic genomes. Several eukaryotic genomes have been completed and several more are soon to be completed. The huge amounts of genomic sequence data are very useful for studying various aspects of the evolution of duplicate genes. This is the first time that evolution of duplicate genes can be studied at the genomic level. To seize this unprecedented opportunity, we propose to pursue the following studies: 1. To develop methods for detecting duplicate genes in a genome and for classifying proteins into families. 2. To develop methods for detecting block duplications in a genome. A computer software package for the methods in (1) and (2) will be developed. 3. To assess the extents of gene duplication in various eukaryotic genomes. For each complete genome we ask: How many duplicate genes (gene families) exist in the genome? How often block duplication occurs? Then in comparison among genomes, we shall ask, "which genes have not been duplicated in any of the genomes studied, which duplicate genes are common to diverse genomes and which are restricted to only certain evolutionary lineages? And why are they so distributed?" 4. To study the rate of gene duplication in a genome. 5. To study the mechanisms of evolution of duplicate genes or how duplicate genes evolve following the duplication event. We shall examine various models for the retention and evolution of duplicate genes.

描述（由申请人提供）：我们的目标是了解流程和真核基因组中重复基因的进化机制。一些真核生物基因组已经完成，更多的基因组即将完成完全的。大量的基因组序列数据对于研究重复基因进化的各个方面。这是第一个是时候可以在基因组水平上研究重复基因的进化了。到抓住这一前所未有的机遇，我们建议采取以下措施研究： 1. 开发检测基因组中重复基因的方法将蛋白质分类为家族。 2. 开发检测基因组中块重复的方法。一台电脑将开发用于(1)和(2)中的方法的软件包。 3. 评估各种真核生物基因组中基因复制的程度。为了每个完整的基因组我们问：有多少重复基因（基因家族）存在于基因组？块重复发生的频率是多少？那么在比较之间基因组中，我们会问，“哪些基因在任何基因组中都没有被复制过” 研究的基因组，哪些重复基因是不同基因组共有的，哪些仅限于某些进化谱系？为什么他们会这样分布式？” 4. 研究基因组中基因复制的速率。 5. 研究重复基因的进化机制或如何重复基因在复制事件后进化。我们将研究各种模型用于重复基因的保留和进化。