Evolution of Duplicate Genes at the Genomic Level

基因组水平上重复基因的进化

• 批准号: 6522061
• 负责人: WEN-HSIUNG LI
• 金额: $ 18.47万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6522061
• 关键词: computer program /software; computer system design /evaluation; eukaryote; evolution; gene duplication; gene expression; gene frequency; genome; mathematical model; microarray technology; statistics /biometry

DESCRIPTION (provided by applicant): Our goal is to understand the process and mechanisms of the evolution of duplicate genes in eukaryotic genomes. Several eukaryotic genomes have been completed and several more are soon to be completed. The huge amounts of genomic sequence data are very useful for studying various aspects of the evolution of duplicate genes. This is the first time that evolution of duplicate genes can be studied at the genomic level. To seize this unprecedented opportunity, we propose to pursue the following studies: 1. To develop methods for detecting duplicate genes in a genome and for classifying proteins into families. 2. To develop methods for detecting block duplications in a genome. A computer software package for the methods in (1) and (2) will be developed. 3. To assess the extents of gene duplication in various eukaryotic genomes. For each complete genome we ask: How many duplicate genes (gene families) exist in the genome? How often block duplication occurs? Then in comparison among genomes, we shall ask, "which genes have not been duplicated in any of the genomes studied, which duplicate genes are common to diverse genomes and which are restricted to only certain evolutionary lineages? And why are they so distributed?" 4. To study the rate of gene duplication in a genome. 5. To study the mechanisms of evolution of duplicate genes or how duplicate genes evolve following the duplication event. We shall examine various models for the retention and evolution of duplicate genes.

描述（申请人提供）：我们的目标是了解过程和 真核基因组中重复基因进化的机制。一些 真核基因组已经完成，很快还有几个 完全的。大量的基因组序列数据对于 研究重复基因演变的各个方面。这是第一个 可以在基因组水平上研究重复基因的演变的时间。到 抓住这个前所未有的机会，我们建议追求以下 研究： 1。开发用于检测基因组中重复基因的方法 将蛋白质分类为家庭。 2。开发用于检测基因组中块重复的方法。计算机 将开发（1）和（2）中方法的软件包。 3。评估各种真核基因组中基因复制的范围。为了 我们问的每个完整基因组：中存在多少重复基因（基因家族） 基因组？多久一次阻止重复一次？然后比较 基因组，我们将问：“哪些基因尚未重复 研究的基因组，复制基因是多种基因组共有的，哪 仅限于某些进化谱系吗？他们为什么这么 分布式？” 4。研究基因组中基因重复的速率。 5。研究重复基因演变的机制或如何复制 基因在重复事件之后进化。我们将检查各种模型 用于重复基因的保留和演变。