Fetal Perfusion System

胎儿灌注系统

• 批准号: 6884182
• 负责人: SARAH E MONTAG
• 金额: $ 9.58万
• 依托单位: ENSION, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884182
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood circulation; congenital heart disorder; embryo /fetus; embryo /fetus surgery; extracorporeal circulation; gestational age; heart /lung bypass; heart surgery; hemodynamics; mathematical model; perfusion; pregnancy circulation; respiratory gas; sheep

DESCRIPTION (provided by applicant): The diagnosis of certain congenital heart defects can now be made as early as 12 weeks of gestation due to advances in fetal echocardiography. Fetal cardiac surgery, which has been investigated since the early 1980s, is an increasingly viable solution to prevent simple cardiac lesions from progressing into serious defects requiring major surgery. The most significant obstacle to successful fetal cardiac bypass has been placental dysfunction, causes of which include blood contact with extracorporeal surfaces, priming substances (maternal blood), and increased placental vascular resistance. The goal of this proposal is to develop a novel fetal cardiac bypass circuit capable of delivering pulsatile flow and adequate gas exchange with minimal priming volume.

描述（由申请人提供）：由于胎儿超声心动图的进步，现在最早可以在妊娠 12 周时诊断某些先天性心脏缺陷。自 20 世纪 80 年代初以来，胎儿心脏手术一直在进行研究，它是一种日益可行的解决方案，可防止简单的心脏病变发展为需要进行大手术的严重缺陷。成功进行胎儿心脏搭桥术的最重要障碍是胎盘功能障碍，其原因包括血液与体外表面的接触、启动物质（母体血液）以及胎盘血管阻力增加。该提案的目标是开发一种新型胎儿心脏旁路回路，能够以最小的预充量提供脉动流和足够的气体交换。