Improved EEG Spatial Resolution via the Normal E-field

通过正常电场提高脑电图空间分辨率

• 批准号: 6998599
• 负责人: ROBERT MATTHEWS
• 金额: $ 13.84万
• 依托单位: QUASAR, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998599
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; clinical biomedical equipment; electric field; electrical measurement; electroencephalography

DESCRIPTION (provided by applicant): Measurement of the complete 3-component electric (E-) field vector has very recently become possible through the development of sensors that can measure free-space electric potential at the sub-microvolt level. This technology has been applied to through-clothing measurement of ECG, with successful preliminary measurements for EEG and ERP. Analysis has already shown that the normal E-field, En, produced by brain sources is more tightly focused in space than the tangential field from the same source when measured through the head. The goal of Phase I is to quantify how a measurement of the E-field in the direction normal to the scalp can be applied to replace or augment conventional electric potential data collected on the scalp surface. 3 specific analysis issues of relevance for EEG, ERP brain source imaging will be investigated. Synthetic data, including sensor effects, will be generated by a sophisticated three-dimensional (3D) numerical simulation supported by analytic calculations. The benefit of measuring the E-field will be quantified by analyzing the data with and without the normal field information, using a modified form of the Brainstorm program. In Phase II, a new type of EEG electrode system that includes sensors of the normal electric field will be constructed together with algorithms that utilize the En information. The system will be directly compared with a 120- electrode Geodesic Sensor Net System on subjects participating in standard evoked potential and EEG experiments. The ability to measure the normal E-field external to the head provides an entirely separate new channel of information about the electrical sources in the brain. If successful this program will contribute to the whole art of EEG signal acquisition, providing a general advance in research and clinical measurement technology. In addition, because the method operates off the body, it should lead to greater patient comfort and facilitate non-medical applications of brain signal measurement, such as alertness monitoring and cognitive state assessment.

描述（由申请人提供）：通过开发可以在亚米克罗夫水平上测量自由空间电势的传感器，对完整的3组分电（E-）场矢量的测量已成为可能。该技术已应用于EEG和ERP的成功初步测量。分析已经表明，与通过头部测量时，由大脑源产生的正常电子场（由大脑源产生的EN比相同源的切向场）更紧密地集中在空间上。第一阶段的目的是量化如何在与头皮的正常方向上的e-Fielt测量，以替换或增强在头皮表面收集的常规电势数据。 3将研究与EEG相关性的特定分析问题，ERP大脑源成像。包括传感器效应在内的合成数据将由由分析计算支持的复杂的三维（3D）数值模拟产生。通过有或没有正常现场信息的数据，使用头脑风暴程序的修改形式来分析数据，可以量化电子场地的好处。在第二阶段，将与使用EN信息的算法一起构建一种新型的EEG电极系统，其中包括正常电场的传感器。该系统将直接与参与标准诱发电位和脑电图实验的受试者进行的120个电极测量传感器网系统进行比较。测量头部外部的正常电子场地的能力提供了有关大脑中电源的完全独立的新信息。如果成功，该计划将有助于脑电信号获取的整个艺术，从而提供研究和临床测量技术的一般进步。此外，由于该方法在身体上运行，因此应导致更大的患者舒适性并促进脑信号测量的非医学应用，例如警报性监测和认知状态评估。