Improved EEG Spatial Resolution via the Normal E-field

通过正常电场提高脑电图空间分辨率

• 批准号: 6998599
• 负责人: ROBERT MATTHEWS
• 金额: $ 13.84万
• 依托单位: QUASAR, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998599
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain electrical activity; clinical biomedical equipment; electric field; electrical measurement; electroencephalography

DESCRIPTION (provided by applicant): Measurement of the complete 3-component electric (E-) field vector has very recently become possible through the development of sensors that can measure free-space electric potential at the sub-microvolt level. This technology has been applied to through-clothing measurement of ECG, with successful preliminary measurements for EEG and ERP. Analysis has already shown that the normal E-field, En, produced by brain sources is more tightly focused in space than the tangential field from the same source when measured through the head. The goal of Phase I is to quantify how a measurement of the E-field in the direction normal to the scalp can be applied to replace or augment conventional electric potential data collected on the scalp surface. 3 specific analysis issues of relevance for EEG, ERP brain source imaging will be investigated. Synthetic data, including sensor effects, will be generated by a sophisticated three-dimensional (3D) numerical simulation supported by analytic calculations. The benefit of measuring the E-field will be quantified by analyzing the data with and without the normal field information, using a modified form of the Brainstorm program. In Phase II, a new type of EEG electrode system that includes sensors of the normal electric field will be constructed together with algorithms that utilize the En information. The system will be directly compared with a 120- electrode Geodesic Sensor Net System on subjects participating in standard evoked potential and EEG experiments. The ability to measure the normal E-field external to the head provides an entirely separate new channel of information about the electrical sources in the brain. If successful this program will contribute to the whole art of EEG signal acquisition, providing a general advance in research and clinical measurement technology. In addition, because the method operates off the body, it should lead to greater patient comfort and facilitate non-medical applications of brain signal measurement, such as alertness monitoring and cognitive state assessment.

描述（由申请人提供）：最近，通过开发能够测量亚微伏级自由空间电势的传感器，完整的三分量电（E-）场矢量的测量已经成为可能。该技术已应用于心电图的穿衣测量，并成功完成了脑电图和ERP的初步测量。分析已经表明，当通过头部测量时，由脑源产生的正常电场 En 比来自同一源的切向场更紧密地聚焦在空间中。第一阶段的目标是量化如何应用垂直于头皮方向的电场测量来取代或增强在头皮表面收集的传统电势数据。 3 具体分析相关问题针对EEG、ERP脑源成像进行研究。包括传感器效应在内的综合数据将通过分析计算支持的复杂三维 (3D) 数值模拟生成。测量电场的好处将通过使用头脑风暴程序的修改形式分析具有和不具有正常场信息的数据来量化。在第二阶段，将构建一种新型脑电图电极系统，其中包括正常电场的传感器以及利用 En 信息的算法。该系统将直接与参与标准诱发电位和脑电图实验的受试者的 120 电极测地传感器网络系统进行比较。测量头部外部正常电场的能力提供了关于大脑中电源的完全独立的新信息通道。如果成功，该计划将为脑电图信号采集的整个艺术做出贡献，为研究和临床测量技术提供全面的进步。此外，由于该方法在体外进行操作，因此可以提高患者的舒适度，并促进大脑信号测量的非医学应用，例如警觉性监测和认知状态评估。