Therapeutics for Pox, Filo and Other Viral Pathogens

痘、丝状病毒和其他病毒病原体的治疗

• 批准号: 6850768
• 负责人: Stewart W. Schneller
• 金额: $ 122.7万
• 依托单位: AUBURN UNIVERSITY AT AUBURN
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6850768
• 关键词: Mononegavirales; Poxviridae; antiviral agents; bioterrorism /chemical warfare; cooperative study; drug design /synthesis /production; microorganism disease chemotherapy; virus diseases

DESCRIPTION (provided by applicant): The possibility for biological terrorism has moved from the realm of speculation into reality. As a consequence, the National Institute of Allergy and Infectious Diseases has identified a number of agents that pose the greatest threat and has recommended that therapeutic agents be developed against them. Among that group of pathogens are smallpox and the viral hemorrhagic fevers (including the filoviruses Ebola and Marburg). In preparation for possible release of smallpox, plans are well underway to avail sufficient quantities of smallpox vaccine for a large number of people. However, within this population, there are individuals who will not be able to tolerate the vaccine or, for pre-existing health and/or age reasons, will not be suitable to receive vaccine protection. Thus, for these and other reasons, therapeutic agent development has been recommended by the NIAID. This proposal deals with two therapeutic goals in this direction: (i) agents for treating smallpox infection for instances where the vaccine was ineffective, not available or not administered for reasons just outlined, and (ii) drugs to counteract the effects of vaccination when administered. For the filoviruses Ebola and Marburg, which manifest themselves differently than smallpox but still produce horrendous effects, there are currently no pre-infection vaccines nor post-infection therapeutics available. To address these situations, plans are put forth for designing and developing drugs that would act by inhibiting viral replicative steps following infection by these viruses. Focus will be on nucleosides and nucleotides that affect, primarily, nucleic acid metabolism. A consortium of 3 chemists and 10 virologists has been assembled for this purpose. Because of the extensive collaborations that have been ongoing for some time by this group of chemists and virologists, it can be expected that promising anti-orthopoxvirus and anti-filovirus agents will be uncovered.

描述（由申请人提供）：生物恐怖主义的可能性已从投机领域转变为现实。结果，美国国家过敏和传染病研究所已经确定了许多构成最大威胁的特工，并建议对他们开发治疗剂。在这组病原体中，有天花和病毒出血狂（包括埃博拉病毒和马堡）。 为了准备可能释放天花，计划正在进行中，以便为许多人提供足够数量的天花疫苗。但是，在这个人群中，有些人将无法容忍疫苗，或者出于预先存在的健康和/或年龄原因，将不适合接受疫苗保护。因此，由于这些和其他原因，NIAID推荐了治疗剂的开发。该提案涉及两个方向上的两个治疗目标：（i）用于治疗天花感染的药物，以疫苗无效，出于概述的原因而无法施用或不给予疫苗，以及（ii）药物来抵消疫苗接种后给予疫苗的影响。 。 对于埃博拉病毒和马堡，它们与天花的表现不同，但仍会产生可怕的影响，目前尚无感染前疫苗或感染后治疗剂。 为了解决这些情况，提出了设计和开发药物的计划，这些药物将通过抑制这些病毒感染后抑制病毒复制步骤来起作用。重点将放在主要影响核酸代谢的核苷和核苷酸上。为此，已经组装了一个由3名化学家和10位病毒学家组成的财团。 由于这组化学家和病毒学家已经进行了一段时间的广泛合作，因此可以预料，有望有希望的抗炎病毒和抗纤维病毒药物会被发现。