ANTI-ORTHOPOXVIRUS DRUG DISCOVERY AND DEVELOPMENT

抗正痘病毒药物的发现和开发

• 批准号: 6374676
• 负责人: Stewart W. Schneller
• 金额: $ 54.04万
• 依托单位: AUBURN UNIVERSITY AT AUBURN
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6374676
• 关键词: Poxviridae; antiviral agents; cooperative study; drug design /synthesis /production; drug screening /evaluation

DESCRIPTION (adapted from applicant's abstract): The possibility of biological terrorism has moved from the realm of speculation into reality. This threat can take several forms. One of the most likely pathogens in such a scenario is smallpox. The same characteristics that made smallpox a dreaded human pathogen, including aerosol infectivity and stability outside a human host, make it a potentially devastating biological weapon. Dissemination of smallpox in a major population center could result in the sudden, simultaneous occurrence of thousands of cases of severe illness. The primary reason for this is that so few people are now protected from infection by prior vaccination as a consequence of the declaration in 1980 of the complete eradication of smallpox. Furthermore, vaccination would be of little benefit to persons already infected by terrorist release of the virus and immediate vaccination of the exposed population might not reduce the infectivity of primary cases to prevent secondary transmission. Vaccine availability and quality would also prevent a massive vaccination effort. Because of these limitations, development of chemotherapeutic agents to combat smallpox infection must be undertaken. No such agents currently exist. To address this need, this proposal presents plans for developing drugs that act by inhibiting the enzymes encoded by the smallpox virus upon infection. Focus will be on nucleosides and nucleotides that effect, primarily, nucleic acid metabolism. A consortium of three chemists and two virologists as project leaders, and a virologist consultant, has been put into place for this purpose.

描述（改编自申请人的摘要）：生物的可能性 恐怖主义已从猜测领域变为现实。 这种威胁 可以采取多种形式。 在这种情况下最可能的病原体之一 是天花。 与使天花成为令人恐惧的人类相同的特征 病原体，包括气溶胶感染性和在人类宿主外的稳定性， 使其成为具有潜在毁灭性的生物武器。 传播 主要人口中心的天花可能会导致突然的、同时发生的 发生数以千计的重症病例。 主要原因是 这是因为现在很少有人能够通过先前的预防措施免受感染 1980 年宣布全面疫苗接种 消灭天花。 此外，接种疫苗也没有什么好处 已被恐怖分子释放病毒感染的人，并立即 对暴露人群进行疫苗接种可能不会降低其传染性 原发病例，防止二次传播。 疫苗供应情况和 质量也会阻碍大规模的疫苗接种工作。 因为这些 对抗天花的化疗药物的局限性和开发 必须进行感染。 目前不存在这样的代理。 致地址 为了满足这一需要，该提案提出了开发药物的计划，这些药物的作用是 抑制天花病毒感染后编码的酶。 重点 将针对主要影响核酸的核苷和核苷酸 代谢。 由三名化学家和两名病毒学家组成的联盟作为项目 为此，已安排了领导者和病毒学家顾问 目的。