ANTI-ORTHOPOXVIRUS DRUG DISCOVERY AND DEVELOPMENT

抗正痘病毒药物的发现和开发

• 批准号: 6216811
• 负责人: Stewart W. Schneller
• 金额: $ 54.75万
• 依托单位: AUBURN UNIVERSITY AT AUBURN
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6216811
• 关键词: Poxviridae; antiviral agents; cooperative study; drug design /synthesis /production; drug screening /evaluation

DESCRIPTION (adapted from applicant's abstract): The possibility of biological terrorism has moved from the realm of speculation into reality. This threat can take several forms. One of the most likely pathogens in such a scenario is smallpox. The same characteristics that made smallpox a dreaded human pathogen, including aerosol infectivity and stability outside a human host, make it a potentially devastating biological weapon. Dissemination of smallpox in a major population center could result in the sudden, simultaneous occurrence of thousands of cases of severe illness. The primary reason for this is that so few people are now protected from infection by prior vaccination as a consequence of the declaration in 1980 of the complete eradication of smallpox. Furthermore, vaccination would be of little benefit to persons already infected by terrorist release of the virus and immediate vaccination of the exposed population might not reduce the infectivity of primary cases to prevent secondary transmission. Vaccine availability and quality would also prevent a massive vaccination effort. Because of these limitations, development of chemotherapeutic agents to combat smallpox infection must be undertaken. No such agents currently exist. To address this need, this proposal presents plans for developing drugs that act by inhibiting the enzymes encoded by the smallpox virus upon infection. Focus will be on nucleosides and nucleotides that effect, primarily, nucleic acid metabolism. A consortium of three chemists and two virologists as project leaders, and a virologist consultant, has been put into place for this purpose.

描述（根据申请人的摘要改编）：生物学的可能性 恐怖主义已从投机的境界转变为现实。 这个威胁 可以采取几种形式。 在这种情况下最有可能的病原体之一 是天花。 使天花成为可怕人类的相同特征 病原体，包括人类宿主外的气溶胶感染性和稳定性， 使其成为潜在的毁灭性生物武器。 传播 主要人口中心的天花可能会导致突然同时发生 发生数千例严重疾病。 主要原因 这是因为现在很少有人受到先验的保护 1980年宣布的疫苗接种 消除天花。 此外，疫苗接种将无益 给已经被恐怖分子释放病毒和立即感染的人 暴露人口的疫苗接种可能不会降低 预防继发传播的主要情况。 疫苗的可用性和 质量还将防止大规模的疫苗接种工作。 因为这些 局限性，开发化学治疗剂以对抗天花 必须进行感染。 目前没有这样的代理。 解决 这项提议的这一需求介绍了开发毒品的计划 抑制感染后天花病毒编码的酶。 重点 将在主要影响核酸的核苷和核苷酸上 代谢。 由三位化学家和两名病毒学家作为项目的财团 为此，领导者和病毒学家顾问已经成立 目的。