Core--Informatics, Biostatistics and data management

核心--信息学、生物统计学和数据管理

• 批准号: 7052512
• 负责人: JEFFREY M. TRENT
• 金额: $ 41.76万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052512
• 关键词: bioinformatics; biomarker; biomedical equipment development; biomedical facility; biotechnology; bioterrorism /chemical warfare; computer data analysis; computer simulation; computer system design /evaluation; cooperative study; data management; experimental designs; functional /structural genomics; high throughput technology; metabolomics; radiation dosage; statistical service /center; statistics /biometry

This Core will provide a variety of informatics and biostatistical analytic support to the Research Projects, other Cores, and the Pilot Projects of the Center for High-Throughput Minimally-Invasive Radiation Biodosimetry. This Core will also provide central, secure hosting for data exchange among all Consortium members. As well as more specific bioinformatics issues described below, this Core will provide general statistical support in terms of experimental design, and statistical data analysis. This Core will also have a central role in the review of proposed Pilot Projects. Central members of the Core are Jeffrey Trent and Michael Bittner at TGen, and Marianthi Markatou at Columbia University, all of whom have international reputations in their field. Direct analytic efforts will center on informatics and specialized statistical support of efforts to develop biodosimeters based on gene expression in lymphocytes (Project 2) and small molecule production in body fluids (Project 3). In order for biomarkers to be useful as biodosimeters, it is important to be able to determine how accurately and effectively the marker measurements allow classification of irradiated individuals on the basis of the radiation doses they have sustained. To do this the Consortium will have to be able to rapidly find those markers that not only separate the classes, but those which do so with the greatest resistance to inter-individual variation and assay noise. The Consortium will also benefit from a clear understanding of the ways in which the fundamental mechanisms of cellular response to radiation give rise to the measurable outcomes in the various assays proposed. In concert with the functional genomics Core and also with Project 3, this Core will analyze functional genomic and metabolomic measurements from the responding cells in most of these assays. This will allow assessments of the common and differential aspects of the genomic/metabolomic response in the various systems, and help us discern where the measurements provide complementary or redundant information. In summary, this Core will provide the bioinformatics that will be crucial to the success of Projects 2 and 3, and will provide statistical support in terms of experimental design and data analysis for all Consortium members.

该核心将为高通量微创辐射生物剂量测定中心的研究项目、其他核心和试点项目提供各种信息学和生物统计分析支持。该核心还将为所有联盟成员之间的数据交换提供集中、安全的托管。除了下面描述的更具体的生物信息学问题外，该核心还将在实验设计和统计数据分析方面提供一般统计支持。该核心还将在审查拟议试点项目方面发挥核心作用。核心成员包括 TGen 的 Jeffrey Trent 和 Michael Bittner，以及哥伦比亚大学的 Marianthi Markatou，他们都在各自的领域享有国际声誉。直接分析工作将集中于信息学和专业统计支持，以开发基于淋巴细胞基因表达（项目 2）和体液中小分子产生（项目 3）的生物剂量计。为了使生物标记物能够用作生物剂量计，重要的是能够确定标记物测量如何准确和有效地根据受辐射个体所承受的辐射剂量对他们进行分类。要做到这一点，联盟必须能够快速找到那些不仅能够区分类别的标记，而且能够最大程度地抵抗个体间变异和检测噪音的标记。该联盟还将受益于对细胞对辐射反应的基本机制如何在提出的各种检测中产生可测量结果的清晰了解。与功能基因组学核心以及项目 3 相配合，该核心将分析大多数检测中响应细胞的功能基因组和代谢组学测量结果。这将允许评估各种系统中基因组/代谢组学反应的共同和差异方面，并帮助我们辨别测量的位置 提供补充或冗余信息。总之，该核心将提供对项目 2 和 3 的成功至关重要的生物信息学，并将为所有联盟成员提供实验设计和数据分析方面的统计支持。