MOLECULAR EVOLUTION OF P. FALCIPARUM AND P VIVAX

恶性疟原虫和间日疟原虫的分子进化

• 批准号: 7024924
• 负责人: Ananias Alberto Escalante
• 金额: $ 6.22万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7024924
• 关键词: Aves; Plasmodium; Plasmodium falciparum; Primates; Rodentias; animal population genetics; antigens; biochemical evolution; circumsporozoite protein; cytochrome oxidase; ethology; gene expression; genetic polymorphism; genetic recombination; genotype; geographic site; host organism interaction; human data; malaria; malaria vaccines; molecular cloning; nucleic acid sequence; polymerase chain reaction; protein kinase; vaccine development

DESCRIPTION (Adapted from the Applicant's Abstract): This proposal seeks to apply concepts from evolutionary biology to the study of both human and non-human malaria parasites, with the broad goal of gaining analyzing their phylogenetic relationships and of characterizing the amount, origin and manner of maintenance of genetic diversity in various genes encoding human candidate immunogens. Four primary aims are to be pursued, including: (1) to establish phylogenetic relationships relating the various mammalian malaria parasites to each other and to those of other Haemosporina, emphasizing the origins and evolutionary history of P. falciparum and P. vivax; (2) using this phylogenetic tree as a base, to identify factors affecting the evolution of major candidate vaccine immunogens; 3) to compare the extent, origin and maintenance of genetic diversity among candidate immunogens from geographically diverse samples of P. falciparum and of P. vivax; and 4) to correlate intra-host parasite genetic diversity and clinical manifestations of disease in P. falciparum-infected children in western Kenya. Overall, the proposed body of work seeks to establish the origins of the malaria parasites, to provide a basis for developing a multivalent malaria vaccine and to define the distribution of genetic diversity among malaria parasites across a broad geographic area.

描述（改编自申请人的摘要）：该提案旨在 将进化生物学的概念应用于人类和人类的研究 非人类疟疾寄生虫，其广泛目标是分析它们的 系统发育关系以及表征数量、起源和方式 维持编码人类候选者的各种基因的遗传多样性 免疫原。追求四个主要目标，包括： (1) 建立 与各种哺乳动物疟原虫相关的系统发育关系 彼此以及其他血孢菌属，强调起源和 恶性疟原虫和间日疟原虫的进化史； (2) 使用该系统发育学 以树为基础，识别影响主要候选进化的因素 疫苗免疫原； 3）比较遗传的程度、起源和维持 来自不同地理的 P. 样本的候选免疫原的多样性。 恶性疟原虫和间日疟原虫； 4) 关联宿主内寄生虫遗传 恶性疟原虫感染疾病的多样性和临床表现 肯尼亚西部的儿童。 总体而言，拟议的工作体系旨在确定 疟疾寄生虫，为发展多价疟疾提供基础 疫苗并确定疟疾遗传多样性的分布 寄生虫遍布广泛的地理区域。

项目成果

Does cotrimoxazole prophylaxis for the prevention of HIV-associated opportunistic infections select for resistant pathogens in Kenyan adults?

用于预防艾滋病毒相关机会性感染的复方新诺明预防措施是否会选择肯尼亚成年人的耐药病原体？

• 发表时间: 2008-09
• 作者: Hamel, Mary J;Greene, Carolyn;Chiller, Tom;Ouma, Peter;Polyak, Christina;Otieno, Kephas;Williamson, John;Shi, Ya Ping;Feikin, Daniel R;Marston, Barbara;Brooks, John T;Poe, Amanda;Zhou, Zhiyong;Ochieng, Benjamin;Mintz, Eric;Slutsker, Laurenc
• 通讯作者: Slutsker, Laurenc

A comparative study of the genetic diversity of the 42kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax.

恶性疟原虫和间日疟原虫裂殖子表面蛋白1 42kDa片段遗传多样性的比较研究。

• 发表时间: 2007-03
• 作者: Pacheco, M Andreina;Poe, Amanda C;Collins, William E;Lal, Altaf A;Tanabe, Kazuyuki;Kariuki, Simon K;Udhayakumar, Venkatachalam;Escalante, Ananias A
• 通讯作者: Escalante, Ananias A

Common origin and fixation of Plasmodium falciparum dhfr and dhps mutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America.

南美洲低传播地区恶性疟原虫 dhfr 和 dhps 突变与磺胺多辛-乙胺嘧啶耐药性的共同起源和固定。

• 发表时间: 2007-06
• 影响因子: 4.9
• 作者: McCollum, Andrea M;Mueller, Kristen;Villegas, Leopoldo;Udhayakumar, Venkatachalam;Escalante, Ananias A
• 通讯作者: Escalante, Ananias A

Molecular evolution and intragenic recombination of the merozoite surface protein MSP-3alpha from the malaria parasite Plasmodium vivax in Thailand.

泰国疟原虫间日疟原虫裂殖子表面蛋白 MSP-3α 的分子进化和基因内重组。

• 发表时间: 2005-07
• 影响因子: 2.4
• 作者: Mascorro, C N;Zhao, K;Khuntirat, B;Sattabongkot, J;Yan, G;Escalante, A A;Cui, L
• 通讯作者: Cui, L

Genetic diversity in the Block 2 region of the merozoite surface protein 1 (MSP-1) of Plasmodium falciparum: additional complexity and selection and convergence in fragment size polymorphism.

恶性疟原虫裂殖子表面蛋白 1 (MSP-1) 块 2 区域的遗传多样性：片段大小多态性的额外复杂性、选择和收敛。

• 发表时间: 2006-09
• 作者: Takala, S L;Escalante, A A;Branch, O H;Kariuki, S;Biswas, S;Chaiyaroj, S C;Lal, A A
• 通讯作者: Lal, A A