Characterizing the spatial epidemiology of urban malaria infection in Accra, Ghana (MUSE)

加纳阿克拉城市疟疾感染的空间流行病学特征 (MUSE)

基本信息

批准号：
10667075
负责人：
Gordon Akanzuwine Awandare
金额：
$ 18.83万
依托单位：
UNIVERSITY OF SOUTH FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10667075
关键词：
Africa African Age Area Catchment Area Cities Clinical Clinical Data Communities Community Surveys Country Cross-Sectional Studies Data Decision Making Dedications Ensure Epidemiology Falciparum Malaria Ghana Goals Health care facility Health system Heterogeneity Household Incidence Individual Infection Intervention Investigation Legal patent Machine Learning Malaria Maps Measures Methods Modeling Molecular Monitor Parasites Patient Self-Report Pattern Persons Plasmodium falciparum Population Prevalence Proxy Public Health Questionnaires Reporting Research Risk Risk Factors Seasons Sensitivity and Specificity Surveys System Techniques Testing Time Urban Population Urbanization climate change design effectiveness evaluation epidemiology study evidence base health data insight interdisciplinary collaboration malaria infection malaria transmission novel primary outcome programs rural area spatial epidemiology spatiotemporal surveillance data time use transmission process trend urban area urban setting vector

项目摘要

SUMMARY Ghana is one of the countries with the greatest Plasmodium falciparum malaria burden, with case trends increasing in recent years. There is a critical gap in research and programmatic efforts to understand malaria epidemiology in urban settings in high-burden countries. The overall research goal of this project is to generate the evidence base to determine strategies to effectively monitor and target interventions appropriate for urban environments in Accra, Ghana, a typical African city in a high-burden country. Through paired clinical incidence data and three household-based cross-sectional surveys in 13 health facility catchment areas, we will: 1) characterize the malaria epidemiology across a transmission season using reported clinical incidence and household-based surveys; 2) Quantify the degree of bias in routine surveillance data due to non-care-seeking malaria infections in an urban setting; 3) Assess the ability of routine malaria surveillance data to identify fine-scale spatial heterogeneity of malaria infections; and 4) determine the degree of infections clustering in households to justify whether targeted strategies are appropriate for the urban setting. The results of this study will fill a critical gap in understanding urban malaria epidemiology and promote data-driven decision-making to ensure malaria control strategies are appropriate and can adapt to the local context.

概括加纳是恶性疟原虫疟疾负担最严重的国家之一，病例趋势近年来不断增加。研究和计划工作在理解方面存在严重差距高负担国家城市环境中的疟疾流行病学。本项目的总体研究目标是生成证据基础以确定有效监测和有针对性的干预措施的策略适合加纳阿克拉这个典型的非洲高负担国家城市的城市环境。通过配对临床发病率数据和对 13 个健康群体进行的三项以家庭为基础的横断面调查在设施服务区域，我们将： 1) 描述整个传播季节的疟疾流行病学特征使用报告的临床发病率和家庭调查； 2）量化日常偏差程度城市环境中非就医疟疾感染的监测数据； 3）评估能力常规疟疾监测数据，以确定疟疾感染的精细空间异质性；和 4) 确定家庭中感染聚集的程度，以证明有针对性的策略是否合理适合城市环境。这项研究的结果将填补理解城市的一个关键空白疟疾流行病学并促进数据驱动的决策，以确保疟疾控制战略得到落实适合并能适应当地情况。