BENZODIAZEPINE USE AND RISK OF DISABILITY IN THE ELDERLY

老年人使用苯二氮卓类药物和残疾风险

• 批准号: 6626426
• 负责人: SHELLY L GRAY
• 金额: $ 10.08万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-15 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6626426
• 关键词: aging; benzodiazepines; disabling disease; disease /disorder proneness /risk; drug adverse effect; epidemiology; functional ability; geriatrics; health care service utilization; human data; human old age (65+); longitudinal human study; meta analysis; outcomes research

DESCRIPTION (Adapted from applicant's abstract): The applicant states that her long-term career goal is to become an independent investigator, focusing on the adverse health outcomes of medication use in the elderly, by utilizing principles of pharmacoepidemology. She currently holds the rank of Assistant Professor in the School of Pharmacy at the applicant institution. She has completed a 2-year research pharmacy fellowship in geriatrics, has conducted research in the area of adverse drug effects in the elderly, and provides clinical services as part of geriatric team. To meet her career objectives, she is proposing to merg her clinical pharmacy background with expertise in epidemiologic methods over a 5-year period by: 1) completing course-work towards a master's degree in the School of Public and Community Health, University of Washington; and 2) conducting supervised research under the guidance of her sponser (David Buchner and co-sponsers (Andreas Stergachis and Andrea LaCroix) Some adverse health consequences of benzodiazepine use in elderly are established and represent a significant public health concern. Yet, according to the applicant, little is known about whether these agents contribute to the disability process. During the proposed award, the applicant plans to determine if benzodiazepine use is associated with the losss of mobility, loss of independence in activities of daily living (ADLs), use of health services, and mortality over a 3- year study period in community dwelling elderly. This research will use data from four large, federally-funded, population-based logitudinal studies of the elderly, containg data on approximately 17,000 individuals. Use of the following data sets is proposed: Established Populations for Epidemiologic Studies of the Elderly; Women's Health and Aging Study; Cardiovascular Health Study; and Group Health Cooperative Demonstration Project. The four outcomes will be evaluated within each dataset, and the data will be poooled for a meta-analysis. Beginning in the third year of the proposed award period, the applicant plans to submit additional competitive grants, and initiate research in other areas related to medication use and adverse health outcomes in the elderly, working closely with her sponsors.

描述（改编自申请人的摘要）：申请人声明 她的长期职业目标是成为一名独立调查员， 重点关注药物使用对健康造成的不良后果 老年人，利用药物流行病学原理。 目前的她 拥有药学院助理教授的职位 申请机构。 她完成了为期 2 年的药学研究 老年病学研究员，在不良反应领域进行了研究 药物对老年人的影响，并提供临床服务作为 老年科团队。 为了实现她的职业目标，她提议合并 她的临床药学背景和流行病学方法方面的专业知识 在 5 年时间内： 1) 完成硕士学位课程 公共卫生学院公共卫生学士 华盛顿； 2）在指导下进行监督研究 她的赞助商（David Buchner）和共同赞助商（Andreas Stergachis 和 安德里亚·拉克鲁瓦） 老年人使用苯二氮卓类药物的一些不良健康后果是 已确定并代表了重大的公共卫生问题。 然而， 据申请人称，对于这些代理人是否 为残疾进程做出贡献。 在拟授奖项期间， 申请人计划确定苯二氮卓类药物的使用是否与 丧失行动能力，丧失日常活动的独立性 三年内的生活水平 (ADL)、医疗服务的使用情况和死亡率 社区居住老年人的学习期。 这项研究将使用数据 来自四项大型、联邦政府资助、基于人口的纵向研究 老年人的数据，包含大约 17,000 人的数据。 使用 建议使用以下数据集： 已建立的人口 老年人流行病学研究；妇女健康与衰老研究； 心血管健康研究；及团体健康合作示范 项目。 将在每个数据集中评估四个结果，并且 数据将被汇集以进行荟萃分析。 从第三部开始 拟议奖励期的年份，申请人计划提交 额外的竞争性资助，并启动其他领域的研究 与老年人的药物使用和不良健康结果有关， 与她的赞助商密切合作。

项目成果

Benzodiazepine use in older adults enrolled in a health maintenance organization.

参加健康维护组织的老年人使用苯二氮卓类药物。

• 发表时间: 2003-09
• 作者: Gray, Shelly L;Eggen, Anne Elise;Blough, David;Buchner, Dave;LaCroix, Andrea Z
• 通讯作者: LaCroix, Andrea Z

Physical inactivity and smoking increase risk for serious infections in older women.

缺乏身体活动和吸烟会增加老年女性严重感染的风险。

• 发表时间: 2000-12
• 影响因子: 6.3
• 作者: Leveille, S G;Gray, S;LaCroix, A Z;Ferrucci, L;Black, D J;Guralnik, J M
• 通讯作者: Guralnik, J M

Risks for frequent antimicrobial-treated infections in postmenopausal women.

绝经后妇女频繁接受抗菌药物治疗感染的风险。

• 发表时间: 2003-02
• 影响因子: 4
• 作者: Boudreau, Denise M;Leveille, Suzanne G;Gray, Shelly L;Black, Douglas J;Guralnik, Jack M;Ferrucci, Luigi;LaCroix, Andrea Z
• 通讯作者: LaCroix, Andrea Z

Can clinical pharmacy services have a positive impact on drug-related problems and health outcomes in community-based older adults?

临床药学服务能否对社区老年人的药物相关问题和健康结果产生积极影响？

• 发表时间: 2004-03
• 作者: Hanlon, Joseph T;Lindblad, Catherine I;Gray, Shelly L
• 通讯作者: Gray, Shelly L

Is the use of benzodiazepines associated with incident disability?

使用苯二氮卓类药物与意外残疾有关吗？

• 发表时间: 2002-06
• 影响因子: 6.3
• 作者: Gray, Shelly L;LaCroix, Andrea Z;Blough, David;Wagner, Edward H;Koepsell, Thomas D;Buchner, Dave
• 通讯作者: Buchner, Dave