Assessing fentanyl test strip use accuracy and fentanyl presence in the non-heroin drug supply

评估芬太尼试纸的使用准确性和非海洛因毒品供应中芬太尼的存在

• 批准号: 10668083
• 负责人: Megan Reed
• 金额: $ 24.45万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668083
• 关键词: Acetaminophen; Address; Anticonvulsants; Benzodiazepines; Case Study; Cities; Consensus; Data; Drug usage; Drug user; Education Gap; Fentanyl; Goals; Harm Reduction; Heroin; Illicit Drugs; Interview; Knowledge; Laboratories; Law Enforcement; Length; Location; Low Prevalence; Methods; Municipalities; Outcome; Overdose; Patient Self-Report; Pennsylvania; Pharmaceutical Preparations; Philadelphia; Preparation; Prevalence; Prevention Measures; Prevention strategy; Process; Reporting; Research; Research Personnel; Sampling; Side; Stimulant; Syncope; Tablets; Technology; Testing; Time; Training; Water; Work; community organizations; community partnership; drug market; drug testing; evidence base; fentanyl contamination; fentanyl overdose; fentanyl test; fentanyl use; non-opioid analgesic; overdose prevention; overdose risk; prescription opioid; prevent; recruit; simulation; sugar; synthetic cannabinoid; test strip; tool

PROJECT ABSTRACT Fentanyl contamination of heroin and other drugs is increasingly common, leading to significant rates of unintentional fentanyl-related overdoses. Fentanyl test strips (FTS) are a low-threshold approach to mitigating fentanyl-related overdose risk among people who use drugs (PWUD). Using FTS, PWUD can dissolve a small quantity of a drug into water to test for the presence of fentanyl. PWUD report that FTS are easy to use with few logistical and environmental barriers associated with use. Moreover, emerging evidence indicates that FTS use positively impacts subsequent actions. In prior work conducted by our team, PWUD in Philadelphia reported exceptionally high rates of positive FTS results on non-heroin drugs, far higher than rates seen in other locations. Possible explanations for these discordant results include saturation of the Philadelphia illicit drug market with fentanyl, incorrect use of FTS, incorrect interpretation of FTS, or a combination of the three. Despite increasing distribution of FTS, no studies to date have explored the accuracy of FTS use by PWUD. In addition, while the prevalence of fentanyl in the heroin supply has been widely documented, it is currently unknown to what extent fentanyl is present in non-heroin drug markets. Based upon the recent findings in Philadelphia reporting alarmingly high rates of FTS positivity with non-heroin drugs and these gaps in current knowledge regarding both FTS use and contamination of the non-heroin drug supply, there is an urgent need to assess the accuracy of FTS use among PWUD and the extent fentanyl is present in the Philadelphia non- heroin drug supply. The long-term goal of this work is to advance overdose prevention measures using FTS and other drug-checking technology in drug markets around the U.S. The overall objective of this proposal is to leverage established municipal and community partnerships in Philadelphia and the use of advanced drug- checking technology to explicate gaps identified between previously detected levels of fentanyl in the drug supply and self-reported results from FTS use among PWUD in Philadelphia. Our objective will be achieved with two specific aims: (1) Determine user process of use and interpretation of FTS and (2) Estimate the true presence of fentanyl in the non-heroin drug supply in Philadelphia, PA. This study will have significant impact by addressing knowledge gaps regarding utility of FTS as a harm reduction strategy and providing actionable evidence regarding the extent of fentanyl presence in non-heroin drugs. We anticipate three outcomes from aims: (1) the identification of educational gaps in the proper use of FTS and interpretation of their results among PWUD, (2) point-in-time data for fentanyl contamination of non-heroin illicit drugs in Philadelphia, and (3) informing ongoing national campaigns to educate PWUD about FTS and overdose prevention strategies. Study findings will enhance evidence-based overdose prevention efforts targeted at supply-side fentanyl contamination and real-world FTS use practices by PWUD.

项目摘要 海洛因和其他毒品的芬太尼污染越来越普遍，导致大量 无意的芬太尼相关过量。芬太尼试纸 (FTS) 是一种低门槛的缓解方法 吸毒者 (PWUD) 中与芬太尼相关的过量风险。使用 FTS，PWUD 可以溶解少量 将一定量的药物放入水中以测试芬太尼的存在。 PWUD 报告称 FTS 易于使用 与使用相关的后勤和环境障碍很少。此外，新出现的证据表明 FTS 使用会对后续行动产生积极影响。在我们团队之前进行的工作中，费城 PWUD 据报告，非海洛因毒品的 FTS 结果阳性率极高，远高于 其他地点。这些不一致结果的可能解释包括费城非法贸易的饱和 芬太尼药品市场、FTS 的不正确使用、FTS 的不正确解释或三者的组合。 尽管 FTS 的分布不断增加，但迄今为止还没有研究探讨 PWUD 使用 FTS 的准确性。在 此外，虽然海洛因供应中芬太尼的流行已被广泛记录，但目前 目前尚不清楚芬太尼在非海洛因毒品市场中的存在程度。根据最近的调查结果 费城报告非海洛因药物的 FTS 阳性率高得惊人，以及当前的这些差距 迫切需要了解有关 FTS 使用和非海洛因毒品供应污染的知识 评估 PWUD 中 FTS 使用的准确性以及费城非非药物中芬太尼的存在程度 海洛因毒品供应。这项工作的长期目标是利用 FTS 推进过量预防措施 以及美国各地药品市场的其他药品检查技术。该提案的总体目标是 利用费城已建立的市政和社区合作伙伴关系以及先进药物的使用 检查技术以解释先前检测到的药物中芬太尼水平之间发现的差距 费城 PWUD 中 FTS 使用的供应和自我报告结果。我们的目标将会实现 有两个具体目标：(1) 确定 FTS 的用户使用和解释过程；(2) 估计真实的 宾夕法尼亚州费城的非海洛因毒品供应中存在芬太尼。这项研究将产生重大影响 通过解决关于 FTS 作为减少危害战略的效用的知识差距，并提供可行的建议 关于非海洛因药物中芬太尼存在程度的证据。我们预计三个结果 目标：(1) 确定正确使用 FTS 方面的教育差距并解释其结果 在 PWUD 中，(2) 费城非海洛因非法药物芬太尼污染的时间点数据，以及 (3) 通报正在进行的全国性运动，以教育残疾人士关于 FTS 和过量预防策略的知识。 研究结果将加强针对芬太尼供应方的循证过量预防工作 PWUD 的污染和现实世界 FTS 使用实践。