Research Training in Alimentary Tract Surgery

消化道外科研究培训

• 批准号: 6854542
• 负责人: DAVID I SOYBEL
• 金额: $ 17.16万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-18 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6854542
• 关键词: Research; Training; Alimentary; Tract; Surgery

DESCRIPTION (provided by applicant): This Program provides research training for young surgeons who plan careers for patient care and investigation in surgical problems of the alimentary tract. Its primary purpose is to prepare these individuals to become independently funded investigators. The program provides intensive, coordinated research training in fundamental aspects of molecular and cell biology, biochemistry and biophysics, organ physiology and pathophysiology, and immunology, as they apply to diseases of the alimentary tract, hepatobiliary system and pancreas. First funded in 1997 as a collaboration between the Departments of Surgery at the Brigham and Women's Hospital and the former Beth Israel Hospital, this program is now expanded to include NIH-funded surgical research laboratories at all major adult teaching hospital affiliates of Harvard Medical School. Current areas of investigation by core preceptor group include: 1) gastro-intestinal mucosal secretion and barrier function (Soybel, Hofer, Hagen); 2) energetics and metabolic derangements of liver in sepsis and shock (Fischer, Hasselgren); 3) gut differentiation and growth responses to starvation or massive resection (Hodin, Ashley, Zinner); 4) cell biology and pathophysiology of acute and chronic pancreatitis (Warshaw); 5) molecular basis of pancreatic cancer growth and metastasis (Callery); 6) tissue engineering as applied to reconstruction and rehabilitation of the alimentary tract (Vacanti, Whang); and 7) evaluation of outcomes and introduction of new technologies in operations on the Digestive System (Zinner, Warshaw, Daley). In addition, a number of young faculty have been recruited to the different Departments of Surgery at HMS, with intention of their development as surgeon-investigators in the field of GI and HPB Surgery. We propose to include these young faculty, under clearly specified circumstances, as comentors of our research fellows, thereby enhancing the environment for learning and providing an environment of mentoring for future mentors. The program will be enriched by opportunities for formal coursework in basic sciences and experimental techniques at Harvard's Medical School and School of Public Health, by interactions with core labs and investigators of the NIH-funded Digestive Diseases Centers (HMS-based and MGH-based), and by participation in clinical and research conferences offered at each institution. The training Program Executive Committee (Soybel, Hodin, Hasselgren) oversees selection of trainees, designation of preceptors, prescription of formal coursework, and participation of trainees in programs teaching ethics and responsible conduct in research. Trainees are selected through a process open to surgical residents or fellows in accredited U.S. Surgical Residency Training Programs. A pro-active process for seeking applications from individuals belonging to under-represented minority groups is coordinated through the Offices for Diversity at HMS and each of the participating institutions

描述（由申请人提供）： 该计划为年轻外科医生提供了研究培训，这些外科医生计划在养殖道的手术问题中为患者护理和调查而进行职业。它的主要目的是使这些人成为独立资助的调查人员。该计划在分子和细胞生物学，生物化学和生物物理学，器官生理学和病理生理学以及免疫学的基本方面提供了深入的协调研究培训，因为它们适用于养殖区，肝脏体系和胰腺的疾病。该计划于1997年首次作为1997年的合作，是杨百翰和妇女医院和前贝丝以色列医院之间的合作，该计划现在已扩大到包括NIH资助的外科手术研究实验室，哈佛医学院的全部成人教学医院分支机构。核心受体组的当前调查领域包括：1）胃粘膜分泌和屏障功能（Soybel，Hofer，Hagen）； 2）败血症和冲击中肝脏的能量和代谢扰动（fischer，hasselgren）； 3）肠道分化和对饥饿或大量切除的生长反应（Hodin，Ashley，Zinner）； 4）急性和慢性胰腺炎（Warshaw）的细胞生物学和病理生理学； 5）胰腺癌生长和转移的分子基础（Callery）； 6）用于重建和康复的组织工程（田，针去田）； 7）评估结果的评估和消化系统操作中新技术的引入（Zinner，Warshaw，Daley）。此外，许多年轻的教职员工已被招募到HMS的不同手术部门，目的是作为GI和HPB手术领域的外科医生进行研究。我们建议在明确特定的情况下，作为研究人员的界人士，包括这些年轻的教师，从而增强了学习的环境，并为未来的导师提供了指导的环境。该计划将在哈佛大学的医学院和公共卫生学院的基础科学和实验技术中进行正式课程的机会，与NIH资助的消化疾病中心（基于HMS和MGH）的研究人员的互动，以及参与每个机构提供的临床和研究会议。培训计划执行委员会（Soybel，Hodin，Hasselgren）负责选择受训者的选择，指定受体，正式课程的处方以及受训者参与教授伦理学和负责任的研究的计划。通过向美国手术居住培训计划中的外科居民或研究员开放的过程，选拔受训者。一个积极主动的过程，是通过属于代表性不足的少数群体的个人的申请