Neurobiology of Social Behavior

社会行为神经生物学

基本信息

批准号：
6822604
负责人：
KIM L HUHMAN
金额：
$ 21.45万
依托单位：
GEORGIA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-12-01 至 2006-11-30
项目状态：
已结题

项目摘要

Social conflict is a major source of stress, and perhaps disease, in a variety of species, including humans. The outcome (i.e., whether an individual is a "winner" or a "loser") of even a relatively brief exposure to social conflict can produce profound and long-lasting changes in subsequent behavior and physiology. For example, when a Syrian hamster is defeated during a brief encounter in the home cage of a larger, aggressive opponent, the defeated hamster will subsequently fail to display normal territorial aggression in its own home cage even when the intruder is a docile, younger animal. This dramatic, yet easily obtainable, change in social behavior has been called conditioned defeat, and we propose that it represents an ethologically relevant and valuable addition to current animal models wherein behavioral responses related to stress, fear and anxiety are studied. The long term goal of this project is to define the neural events that trigger the profound changes in behavior that occur during conditioned defeat. There are currently no published data on the neural elements that regulate conditioned defeat. We propose that the basolateral amygdala, central nucleus of the amygdala and the bed nucleus of the stria terminalis (BNST) are critical for the acquisition and expression of conditioned defeat. This hypothesis was developed from several converging lines of evidence from studies on the neurobiology of defensive/submissive behaviors and of fear, as well as from strong preliminary data generated in our laboratory. The proposed studies will not only provide the first information on the anatomical sites mediating conditioned defeat, but they will also provide initial information on the neurochemical signals involved.

社会冲突是包括人类在内的各种物种中的压力，也许是疾病的主要来源。即使是相对简短的社会冲突暴露，也可以在随后的行为和生理学上产生深刻而持久的变化。例如，当叙利亚仓鼠在一个更大，侵略性对手的家庭笼子中的短暂相遇中被击败时，即使入侵者是一只温顺的年轻动物，被击败的仓鼠将在自己的家居笼中表现出正常的领土侵略。这种戏剧性但很容易获得的社会行为变化称为有条件的失败，我们建议它代表了与当前动物模型的伦理学相关和有价值的补充，在这些动物模型中，研究了与压力，恐惧和焦虑有关的行为反应。该项目的长期目标是定义触发条件失败期间行为的深刻变化的神经事件。目前尚无有关调节条件失败的神经因素的发布数据。我们提出，基底外侧杏仁核，杏仁核的中央核和基质末端（BNST）的床核对于有条件失败的获取和表达至关重要。这一假设是从关于防御/服从行为和恐惧的神经生物学以及我们实验室中产生的强大初步数据的几个融合证据中提出的。拟议的研究不仅将提供有关介导条件失败的解剖部位的第一个信息，而且还将提供有关涉及的神经化学信号的初始信息。