Combined Pharmaco/Behavior Therapy in Adolescent Smokers

青少年吸烟者的药物/行为联合治疗

• 批准号: 6915665
• 负责人: Himanshu P Upadhyaya
• 金额: $ 32.85万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915665
• 关键词: adolescence (12-20); behavior therapy; behavioral /social science research tag; bupropion; clinical research; clinical trials; counseling; drug screening /evaluation; human subject; human therapy evaluation; nicotine; patient oriented research; smoking cessation; tobacco abuse prevention

DESCRIPTION (provided by applicant): Although cigarette smoking has recently declined in adolescents, it remains a major health concern because adolescence is a critical period for smoking initiation. Most adult smokers (80%) initiate smoking prior to age 18. Cigarette smoking not only causes significant morbidity and mortality, but also leads to a significant economic burden. Fifty percent of all smokers die due to smoking related illnesses. Even though adolescence is a crucial period for initiation of smoking and progression to regular smoking, there is a lack of evidence for effective treatments for adolescent smokers. Several approaches have been tried with equivocal results. Buproprion SR is efficacious in promoting smoking cessation in adult smokers. Our pilot data suggests that buproprion may ALSO be efficacious in adolescents. Contingency management (CM) has been shown to be efficacious in the treatment of a number of substance use disorders in adults, including smoking cessation. CM has also been shown to be efficacious for increasing retention of subjects in treatment trials. The use of CM in adolescents is under explored. The objective of this proposal is to examine the relative efficacy of medication (buproprion SR), CM and medication + CM for smoking cessation and treatment retention for smoking cessation in adolescents. The specific aims of the proposed project are: 1) to examine the efficacy of treatment with buproprion SR in adolescents with nicotine dependence. 2) To examine the efficacy of contingency management (CM) + buproprion SR for improving retention and smoking cessation outcomes as compared to buproprion SR treatment alone, in adolescent smokers. 3) To examine the efficacy of treatment with CM in adolescent smokers. The proposed design is a 2x2 balanced factorial design with four treatment groups: 1) buproprion SR only, 2) buproprion SR + CM, 3) CM + placebo, 4) placebo only. Two hundred and sixteen participants will be urn randomized to one of the four conditions. Primary dependent variable will be continuous abstinence and salivary cotinine levels. The total duration of the study will be 12 weeks (1-week medication titration, 4 weeks of active intervention and a 12-week follow-up. Results of the study will help improve the current state of knowledge for smoking cessation in adolescent smokers.

描述（由申请人提供）： 尽管青少年吸烟最近下降了，但它仍然是一个主要的健康问题，因为青春期是吸烟开始的关键时期。大多数成年吸烟者（80％）在18岁之前引发吸烟。吸烟不仅会引起明显的发病率和死亡率，而且会导致巨大的经济负担。所有吸烟者中有50％因吸烟相关疾病而死亡。即使青春期是开始吸烟和进行定期吸烟的关键时期，但缺乏有效治疗青少年吸烟者的证据。已经尝试了几种模棱两可的结果。 Buproprion SR有效地促进成人吸烟者的戒烟。我们的试点数据表明，在青少年中，安丁式植物也可能​​有效。应急管理（CM）已被证明可以有效地治疗成年人（包括戒烟）的许多药物使用障碍。 CM也已被证明可以有效地增加治疗试验中受试者的保留率。在探索青少年中使用CM。 该提案的目的是检查药物（Buproprion SR），CM和药物 + CM的相对疗效，以戒烟和治疗保留量，以避免青少年的戒烟。拟议项目的具体目的是：1）检查丁丁型SR治疗在具有尼古丁依赖性的青少年中的疗效。 2）在青春期吸烟者中，与单独的布丁剂SR治疗相比，要检查应急管理（CM） + Buproprion SR的疗效。 3）检查CM治疗在青少年吸烟者中的疗效。 所提出的设计是一个2x2平衡的阶乘设计，具有四个治疗组：1）仅布丁sr，2）Buproprion Sr + CM，3）CM +安慰剂，4）仅安慰剂。将有26名参与者随机分为四个条件之一。主要的因变量将是连续的戒酒和唾液可替宁水平。该研究的总持续时间为12周（1周的药物滴定，4周的主动干预和12周的随访。该研究的结果将有助于改善青少年吸烟者的吸烟戒烟的当前知识状态。