MENSTRUAL CYCLE EFFECTS ON SMOKING CESSATION AND CUE REACTIVITY

月经周期对戒烟和提示反应的影响

• 批准号: 7719617
• 负责人: Himanshu P Upadhyaya
• 金额: $ 0.12万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719617
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Cues; Double-Blind Method; Exposure to; Funding; Grant; Human; Impulsivity; Institution; Laboratories; Luteal Phase; Measures; Menstrual cycle; Ovarian hormone; Patient Self-Report; Pharmacotherapy; Randomized; Relapse; Research; Research Personnel; Resources; Smoking; Source; Time; Treatment outcome; United States National Institutes of Health; Woman; base; nicotine patch; response; smoking cessation; varenicline

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a double-blind, randomized smoking cessation trial for women in which the timing of quit attempts, either during the follicular or the luteal phase biologically verified is crossed with pharmacotherapy transdermal nicotine patch vs. varenicline. Prior to treatment initiation, all subjects will participate in a single smoking cue reactivity session. This laboratory-based assessment will involve exposure to standardized smoking and neutral comparison cues. By tying together a human laboratory cue-reactivity paradigm developed during the initial funding period with a treatment outcome study, to assess whether pre-treatment responses to smoking cues predict measures of treatment outcome. In addition to the cue reactivity assessment, laboratory-based and self-reported measures of impulsivity will be collected to better understand the relationship between cue reactivity, impulsivity and relapse and the impact of ovarian hormones and menstrual cycle on these relationships.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这是一项针对妇女的双盲，随机的戒烟试验，在卵泡或黄体期生物学验证期间，戒烟尝试的时间与药物治疗经疗法的尼古丁斑块与varenicline进行了交叉。在治疗开始之前，所有受试者将参加一次吸烟提示反应性。这项基于实验室的评估将涉及暴露于标准化的吸烟和中性比较线索。通过将人类实验室提示反应性范式绑在一起，并在初始资金期间开发了治疗结果研究，以评估对吸烟提示的预处理响应是否预测治疗结果的措施。除了提示反应性评估外，还将收集基于实验室和自我报告的冲动度度量，以更好地了解提示反应性，冲动性和复发性以及卵巢激素与月经周期对这些关系的影响之间的关系。