Hormones in Sex-different Developmental Psychopathology

性别不同发育精神病理学中的激素

• 批准号: 6872701
• 负责人: JOEL T NIGG
• 金额: $ 16.32万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6872701
• 关键词: adolescence (12-20); androgens; attention deficit disorder; behavioral /social science research tag; child psychology; children; clinical research; eating disorders; gender difference; hormone metabolism; hormone regulation /control mechanism; human puberty; hypothalamic hormones; hypothalamic pituitary adrenal axis; laboratory rat; neuropsychological tests; neuropsychology; pituitary hormones; psychopathology; questionnaires

DESCRIPTION (provided by applicant): This is an R-21 submission that responds to the need for translational research initiatives to apply basic science advances to clinical problems. The project would bring together a team of experienced basic scientists who are experts in hormones, behavior, and development with clinical researchers who study two different clinical syndromes at different levels of analysis. The clinical domains were selected for their distinctly different sex-risk profiles, and because for each domain hormone modulation of the disorder's behavioral expression has been hypothesized but not well-investigated: attention-deficit hyperactivity disorder (ADHD) and eating disorders (EDs). The team would also include expertise in animal models of learning, attention, and cognition, so that component mechanisms underlying behavioral expression can be examined. The team also includes expertise in hormone studies of psychiatric populations with depression. Expertise is also present in environmental hormone disrupting chemicals that are suspected by many scientists of altering cognitive and physical development in subtle ways. Thus, the team will have broad expertise that is designed to foster novel cross-cutting translational research planning and prioritizing in order to foster development of a coherent translational research agenda that can examine the contribution of hormones and hormone disruptors and neuromodulators to sex differences in behavioral expression of psychopathology in multiple domains. Regular meetings of this broadly composed team would be held to assure development of this agenda. In addition, under the award, key pilot studies will be conducted to examine (a) circulating hormonal correlates of cognitive and behavioral functioning in children, adolescents, and young adult males and females with ADHD, (b) hormone moderation of pubertal changes in eating disorder symptoms in a non-clinical human sample expected to be free of dietary disruption of hormonal status, (c) cognitive and affective correlates of background contaminant (PCB and DDE) exposures in clinical and non-clinical human samples using executive function probes not previously applied to this question, and (d) key animal experiments to evaluate whether hormonal effects can explain previously-observed sex differences in learning in animal models of ADHD. Expected outcomes of the award are knowledge about the feasibility and areas of greatest promise for these novel research directions, accompanied by a coherent translational research agenda that can culminate in additional cross-cutting research initiatives.

描述（由申请人提供）：这是一份 R-21 提交材料，旨在满足转化研究计划将基础科学进展应用于临床问题的需求。该项目将汇集一组经验丰富的基础科学家，他们是激素、行为和发育方面的专家，以及临床研究人员，他们在不同的分析水平上研究两种不同的临床综合症。选择临床领域是因为其明显不同的性别风险特征，并且因为对于每个领域，激素对疾病行为表达的调节已经被假设但没有得到充分研究：注意力缺陷多动障碍（ADHD）和饮食失调（ED）。该团队还将包括学习、注意力和认知动物模型方面的专业知识，以便可以检查行为表达背后的组成机制。该团队还拥有抑郁症精神病人群激素研究方面的专业知识。在破坏环境激素的化学物质方面也存在专业知识，许多科学家怀疑这些化学物质会以微妙的方式改变认知和身体发育。因此，该团队将拥有广泛的专业知识，旨在促进新颖的跨领域转化研究规划和优先顺序，以促进制定连贯的转化研究议程，该议程可以检查激素、激素干扰物和神经调节剂对行为性别差异的贡献精神病理学在多个领域的表达。这个由广泛组成的团队将定期举行会议，以确保该议程的发展。此外，根据该奖项，将进行关键的试点研究，以检查（a）患有多动症的儿童、青少年和年轻成年男性和女性的认知和行为功能的循环激素相关性，（b）青春期饮食变化的激素调节非临床人类样本中的疾病症状预计不会受到荷尔蒙状态的饮食干扰，(c) 临床和非临床人类中背景污染物（PCB 和 DDE）暴露的认知和情感相关性使用先前未应用于该问题的执行功能探针的样本，以及（d）关键动物实验，以评估激素效应是否可以解释先前在多动症动物模型中观察到的学习性别差异。该奖项的预期成果是了解这些新颖研究方向的可行性和最有希望的领域，并附有连贯的转化研究议程，最终可以产生额外的跨领域研究举措。