Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors

产前性类固醇、双酚 A、邻苯二甲酸盐和性别二态行为

• 批准号: 8587520
• 负责人: Joseph M Braun
• 金额: $ 20.1万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-14 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8587520
• 关键词: 8 year old; 9 year old; Address; Affect; Aggressive behavior; Amniotic Fluid; Androgens; Androstenedione; Animals; Archives; Area; Attention deficit hyperactivity disorder; Attenuated; Autistic Disorder; Award; Behavior; Behavioral; Biological; Biological Markers; Birth; Boston; Brain; Chemicals; Child; Childhood; Clinical; Data; Disease; Endocrine Disruptors; Endocrine system; Endocrinology; Environment; Epidemiologist; Epidemiology; Estradiol; Estrogens; Estrone; Exposure to; Female; Fetal Development; Gonadal Steroid Hormones; Health; Human; Individual; Infant; Institution; Instruction; Intervention; Knowledge; Learning; Learning Disabilities; Measures; Meconium; Mediating; Medical; Memory; Mental Depression; Mentors; Mentorship; Methods; Nature; Outcome; Outcome Measure; Pathway interactions; Performance; Perinatal Exposure; Phase; Play; Population; Pregnancy; Pregnant Women; Process; Psychometrics; Public Health; Radial; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Rodent; Role; Sampling; Sex Characteristics; Short-Term Memory; Testing; Testosterone; Time; Toxicant exposure; Training; Umbilical Cord Blood; United States; Urine; Validation; Visuospatial; Work; abstracting; analog; arm; bisphenol A; career; cohort; computerized; critical period; environmental chemical; environmental chemical exposure; experience; fetal; improved; male; morris water maze; multidisciplinary; neurobehavior; neurobehavioral; neurobehavioral disorder; neurobehavioral test; neurodevelopment; neurotoxicity; novel; performance tests; phthalates; prenatal; prospective; public health relevance; sex; skills; symposium; urinary; virtual

Abstract: The fetal brain is uniquely sensitive and environmental chemical exposures and dysregulation of the endocrine system may increase the risk of adverse neurobehavioral outcomes like autism, attention-deficit/hyperactivity disorder, or depression. Under the mentorship of Drs. Bellinger and Hauser, this training and research plan will build upon Dr. Braun's expertise as an environmental epidemiologist and prepare him for a career studying endocrine disrupting compounds (EDCs) and their impact on hormonal systems and childhood neurodevelopment. Dr. Braun has never received formal training in these areas and few researchers possess this unique cross-disciplinary expertise. During the K99-phase of this award Dr. Braun will use tutorials, seminars/conferences, and didactic instruction to gain additional training in: 1) endocrinology concepts and the impact of environmental chemicals on the endocrine system; 2) psychometric test selection, administration, validation, and interpretation; and 3) childhood neurodevelopment. This training will be applied in an original research project where Dr. Braun will administer computerized tests of visuospatial ability to 25 children from Dr. Hauser's Environment and Reproductive Health (EARTH) study under the guidance of both Drs. Hauser and Bellinger. These computerized tests are analogues of the Morris Water Maze and Radial Arm Maze, which are used in animal studies of neurotoxicity. Using these new skills and the prospective Health Outcomes and Measures of the Environment (HOME) birth cohort, Dr. Braun will address two specific aims during the R00- phase of this award: 1) determine if gestational BPA/phthalate exposure is associated with visuospatial ability in 300 children and if sex modifies these associations and 2) determine if gestational BPA/phthalate exposure is associated with meconium sex steroid concentrations in 330 infants. Dr. Braun is well suited to carry out this research because of his prior training and the unique resources offered by his mentors, advisors, and institution. This proposed training and research will enable him to study the impact of EDCs on other hormonal systems and whether they increase the risk of adverse childhood behavioral outcomes. The examination of sex steroids will advance our knowledge of potential biological mechanisms of EDC action and the use of neurobehavioral tests with animal analogues will improve comparisons between epidemiological and animal studies.

抽象的： 胎儿大脑具有独特的敏感和环境化学暴露和内分泌的失调 系统可能会增加不良神经行为结局的风险，例如自闭症，注意力缺陷/多动症 障碍或抑郁症。在博士的指导下。贝林格和豪瑟（Bellinger and Hauser），该培训和研究计划将 以布劳恩博士为环境流行病学家的专业知识为基础，并为他的职业学习做好准备 内分泌破坏化合物（EDC）及其对荷尔蒙系统和童年的影响 神经发育。布劳恩博士从未在这些领域接受过正规培训，很少有研究人员拥有 这个独特的跨学科专业知识。在该奖项的K99期间，布劳恩博士将使用教程， 研讨会/会议和教学教学，以获得其他培训：1）内分泌概念和 环境化学物质对内分泌系统的影响； 2）心理测试选择，管理， 验证和解释； 3）儿童时期的神经发育。该培训将用于原始 研究项目Braun博士将对25名儿童的视觉空间能力进行计算机化测试 豪瑟（Hauser）博士的环境和生殖健康（EART）在两家DR的指导下进行了研究。豪瑟 和贝林格。这些计算机测试是莫里斯水迷宫和径向臂迷宫的类似物， 用于神经毒性的动物研究。使用这些新技能以及潜在的健康成果以及 环境措施（家庭）出生队列，布劳恩博士将在R00-期间针对两个具体目标 该奖项的阶段：1）确定妊娠BPA/邻苯二甲酸盐是否与视觉空间能力有关 在300名儿童中，如果性别修改了这些关联，2）确定妊娠BPA/邻苯二甲酸盐暴露于 与330名婴儿的胎粪性类固醇浓度有关。布劳恩博士非常适合执行此操作 由于他先前的培训以及他的导师，顾问和他提供的独特资源而进行的研究 机构。这项拟议的培训和研究将使他能够研究EDC对其他激素的影响 系统以及它们是否增加了不利儿童行为结果的风险。性检查 类固醇将提高我们对EDC作用潜在生物学机制的了解和使用 动物类似物的神经行为测试将改善流行病学和动物的比较 研究。