A Residential Dust Control Intervention to Reduce Early Childhood Exposure toChemical Mixtures

住宅灰尘控制干预措施，以减少幼儿接触化学混合物

基本信息

批准号：
10662226
负责人：
Joseph M Braun
金额：
$ 16.2万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-08 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10662226
关键词：
3 year old Adult Age Asthma Behavior Biological Markers Biometry Birth Body Burden Chemical Exposure Child Child Health Child Welfare Childhood Childhood Injury Cognitive Cohort Studies Consensus Data Development Disease Dust Electronics Endocrine Disruptors Environment Environmental Health Epidemiology Ethnic Origin Exposure to Family Flame Retardants Foundations Future Goals Hand Health Home House Dust Hypersensitivity Individual Intervention Intervention Studies Knowledge Life Link Measures Mediating Obesity Ohio Oral cavity Organophosphates Outcome Parents Pathway interactions Policies Poly-fluoroalkyl substances Population Pregnant Women Problem behavior Race Randomized Randomized, Controlled Trials Recommendation Rhode Island Sampling Serum Source Techniques Time building materials critical period design disability early childhood effective intervention evidence based guidelines exposure pathway health data improved injury prevention lead exposure personal care products phthalates polybrominated diphenyl ether preventive intervention residence sex therapy design trial design trial enrollment urinary

3 year old Adult Age Asthma Behavior Biological Markers Biometry Birth Body Burden Chemical Exposure Child Child Health Child Welfare Childhood Childhood Injury Cognitive Cohort Studies Consensus Data Development Disease Dust Electronics Endocrine Disruptors Environment Environmental Health Epidemiology Ethnic Origin Exposure to Family Flame Retardants Foundations Future Goals Hand Health Home House Dust Hypersensitivity Individual Intervention Intervention Studies Knowledge Life Link Measures Mediating Obesity Ohio Oral cavity Organophosphates Outcome Parents Pathway interactions Policies Poly-fluoroalkyl substances Population Pregnant Women Problem behavior Race Randomized Randomized, Controlled Trials Recommendation Rhode Island Sampling Serum Source Techniques Time building materials critical period design disability early childhood effective intervention evidence based guidelines exposure pathway health data improved injury prevention lead exposure personal care products phthalates polybrominated diphenyl ether preventive intervention residence sex therapy design trial design trial enrollment urinary

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项目摘要

Abstract Exposure to endocrine disrupting chemicals (EDCs) during critical periods of development are linked to adverse child health outcomes, including asthma/allergies, behavior problems, IQ decrements, and obesity. Phthalates, flame retardants, and perfluoroalkyl substances (PFAS) are EDCs found in residential dust due to their use in home furnishings, building materials, electronics, and personal care products. Children are exposed to these EDCs as a mixture over the first years of life, often at higher levels than adults. Despite growing consensus that EDC exposures must be reduced, we lack effective interventions to decrease children’s exposure to EDC mixtures in their homes, where they spend the majority of their time. Thus, it is imperative to quantify the contribution of EDC mixtures in residential dust to children’s EDC mixture body burden and determine if interventions that reduce residential dust EDC mixtures effectively diminish childhood exposure to EDC mixtures. We will address this gap in knowledge using data from the Health Outcomes and Measures of the Environment (HOME) Study, a previously conducted randomized controlled trial that enrolled pregnant women from Cincinnati, Ohio and followed their children until age 3 years. We repeatedly collected biospecimens, residential dust samples, and other data from ~200 children ages 1 to 3 years. Using these existing data, we will: (1) Estimate the extent that exposure to EDC mixtures in residential dust is related to children’s EDC mixture body burden; (2) Determine if an intervention designed to reduce residential dust can lower children’s EDC mixture body burden; and (3) Quantify the extent that EDC mixtures in residential dust mediate the relation between an intervention designed to lower residential dust and children’s EDC mixture body burden. Moreover, we will determine if these associations differ by child sex, race/ethnicity, hand-to- mouth behavior, residence type (single vs. multi-family), and residential cleanliness. This solutions-oriented proposal includes experts in EDCs, epidemiology, biostatistics, intervention studies, and children’s environmental health. Together, we will efficiently determine if residential dust control can decrease children’s exposure to EDC mixtures. These results will serve as a basis to design a randomized controlled trial to reduce exposure to EDC mixtures using an ongoing cohort study in Rhode Island. In the absence of population-level interventions to mitigate children’s EDC exposure, our study may provide families and clinicians with evidence- based recommendations about the efficacy of residential dust control to reduce exposure EDC mixtures.

抽象的在关键开发期间，暴露于内分泌破坏化学物质（EDC）与不良儿童健康结果，包括哮喘/过敏，行为问题，智商减少和肥胖。邻苯二甲酸盐，阻燃剂和全氟烷基物质（PFA）是由于居民尘埃发现的EDC 它们用于家具，建筑材料，电子产品和个人护理产品。孩子是在生命的头几年中，以这些EDC作为混合物，通常比成年人更高。尽管越来越多的共识，即EDC暴露必须减少，我们缺乏有效的干预措施来减少儿童在家中大部分时间都在家中接触EDC混合物。那是必须量化住宅灰尘中EDC混合物对儿童EDC混合体的贡献负担并确定减少居民的干预措施是否有效地减少了童年暴露于EDC混合物。我们将使用来自健康成果的数据来解决知识的差距，环境研究的度量（家庭）研究，这是一项先前进行的随机对照试验来自俄亥俄州辛辛那提的孕妇，跟随孩子直到3岁。我们反复收集生物测量，居民尘埃样本和其他约200名1至3岁儿童的数据。使用这些现有数据，我们将：（1）估计住宅灰尘中接触EDC混合物的程度与儿童EDC混合体伯恩；（2）确定旨在减少居民灰尘的干预措施是否可以较低儿童的EDC混合体伯恩；（3）量化EDC在住宅灰尘中混合的程度调解旨在降低居民灰尘和儿童EDC混合物的干预措施之间的关系身体负担。此外，我们将确定这些关联是否因儿童性别，种族/种族，手向方式而有所不同嘴巴行为，居住类型（单与多户家庭）和住宅清洁度。这个面向解决方案提案包括EDC，流行病学，生物统计学，干预研究和儿童的专家环境健康。一起，我们将有效地确定居民尘埃控制是否可以减少儿童的暴露于EDC混合物。这些结果将作为设计随机对照试验以减少的基础使用Rhode Island的一项正在进行的队列研究接触EDC混合物。在没有人口水平的情况下减轻儿童EDC暴露的干预措施，我们的研究可能为家庭和临床医生提供证据 - 基于有关居民防尘效率以减少暴露EDC混合物的建议。