Graduate Training at the Chemistry Biology Interface

化学生物学接口研究生培训

• 批准号: 6893417
• 负责人: RALPH M POLLACK
• 金额: $ 13.29万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6893417
• 关键词: Graduate; Training; Chemistry; Biology; Interface

DESCRIPTION (provided by applicant): This proposal requests funding for an initiative at the Chemistry/Biology Interface (CBI). This program was started at UMBC in 1998 to provide an opportunity for chemistry students to become conversant in the biological sciences and students in the biological sciences to become familiar with chemistry. To date, eleven highly qualified students have been recruited to this program, and all of these students are performing very well. Students in the UMBC CBI program will be registered in either the Ph.D. program in chemistry (CHEM), the joint biochemistry Ph.D. program (BIOC) with the University of Maryland, Baltimore (UMB) or the Ph.D. program in Molecular and Cell Biology (MOCB). Dissertation mentors for these students can come from three UMBC departments (Chemistry & Biochemistry, Biological Sciences or Chemical & Biochemical Engineering) and one department at UMB (Department of Biochemistry & Molecular Biology). Cross-disciplinary training will be ensured by having each student (1) complete a rotation in both a biologically-oriented laboratory and a chemically-oriented laboratory; (2) take an advanced course in both disciplines; (3) enroll in a yearly course entitled "Issues at the Chemistry/Biology Interface;" (4) participate in an annual CBI Workshop; and (5) attend seminars and meetings with a focus on interdisciplinary work at the CBI. Research interests of the participating faculty span a wide variety of areas from photochemistry, through bioanalytical chemistry, synthetic chemistry and enzymology to structural biology, cell biology and immunology. Research areas of current students in the program are: The Role of Ribosomal Proteins S3, S4, and S5 in Translation; Characterization of Small Heat Shock Protein Hsp 17.7 via Molecular Biology and Mass Spectrometry Analysis; Separation and Detection of Varying Nucleic Acid Conformations and Sequences; Applications of Time-Resolved Linear Dichroism Spectroscopy; Activation Enthalpies and Entropies for Isomerization of 5-Androstene-3,17-dione by 3-Oxo-?5-steroid Isomerase; Characterization of Protein-RNA Complexes within the HIV-1 ?-Site by High Resolution FT-ICR Mass Spectrometry; Advanced Applications of In Vitro Microdialysis for Bioactive Thiocompounds; Mechanisms of MHC class II peptide loading in endogenous tumor antigen presentation; NMR Studies of HIV-2 Genome Recognition. Regular meetings of the trainees will ensure that they are exposed to a wide variety of topics at the CBI.

描述（由申请人提供）：该提案要求在化学/生物学接口（CBI）的一项计划中提供资金。 该计划于1998年在UMBC启动，为化学学生提供了一个在生物科学和生物科学的学生中变得熟悉化学的机会。 迄今为止，已经招募了11名高素质的学生参加该计划，所有这些学生的表现都很好。 UMBC CBI计划中的学生将在博士学位上注册。化学计划（Chem），联合生物化学博士学位与马里兰大学，巴尔的摩大学（UMB）或博士学位的计划（BIOC）。分子和细胞生物学（MOCB）的程序。 这些学生的论文导师可以来自UMBC的三个UMBC部门（化学与生物化学，生物科学或化学与生物化学工程），以及UMB（生物化学与分子生物学系）的一个部门。 通过让每个学生（1）在生物学导向的实验室和化学导向的实验室中完成旋转，可以确保跨学科培训； （2）在两个学科中都要高级课程； （3）参加年度课程，标题为“化学/生物学接口上的问题”； （4）参加年度CBI研讨会； （5）参加CBI跨学科工作的研讨会和会议。参与教师的研究兴趣跨越各种领域，从光化学到生物分析化学，合成化学和酶学到结构生物学，细胞生物学和免疫学。 该计划中当前学生的研究领域是：核糖体蛋白S3，S4和S5在翻译中的作用；通过分子生物学和质谱分析来表征小热激蛋白HSP 17.7；分离和检测不同的核酸构象和序列；时间分辨的线性二色性光谱的应用；通过3-氧 - 5-螺旋异构酶对5- androstene-3,17-二酮异构化的激活焓和熵；高分辨率FT-ICR质谱法对HIV-1？位置中蛋白RNA复合物的表征；体外微透析的高级应用用于生物活性硫代复合；内源性肿瘤抗原表现中MHC II类肽加载的机理； HIV-2基因组识别的NMR研究。 受训人员的定期会议将确保他们在CBI上接触过各种各样的主题。