Genetic Models of Cardiovascular Renal & Pulmonary

心血管肾遗传模型

• 批准号: 6894855
• 负责人: MARIO R CAPECCHI
• 金额: $ 18.59万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6894855
• 关键词: Genetic; Models; Cardiovascular; Renal; Pulmonary

DESCRIPTION (provided by applicant): We propose the creation of a multidisciplinary Research Training Program that will integrate the expertise of leading clinical and fundamental research scientists at the University of Utah in the use of animal models to investigate genetic mechanisms underlying cardiovascular, renal and pulmonary diseases. We will offer post-doctoral training (clinical-scientists or Ph.D.), graduate training, and short-term training in the use of animals to investigate genes and pathways involved in disease, with the primary goals of improving diagnosis and identifying new drug targets for treatment of common cardiovascular, renal, and pulmonary diseases. Expertise must be developed not only in generating genetically altered animals but also in characterizing and analyzing their phenotypes. Trainees will be exposed to the broad range of emerging technologies in the fields of gene manipulation, quantitative genetics, functional genomics, biochemistry, physiology, imaging, behavior, bioinformatics and statistics required to carry out comprehensive research in the genetics of common disease. Thirty six faculty members from clinical and basic sciences departments will serve as preceptors for the trainees, drawn on one hand from the Clinical Divisions or Departments of Cardiology, Endocrinology, Hematology, Nephrology, Pulmonary Division, Pediatrics, and Medical Genetics, and on the other hand from the Basic Sciences Departments or Divisions of Human Genetics, Biochemistry, Medical Informatics, Genetic Epidemiology, Biomathematics, Computer Science and Mathematics. The didactic part of the Training Program at both the Post-Graduate and Graduate levels are already in place at the University. Dual mentoring of individual students by faculty from clinical and basic sciences departments, together with the breath of perspective developed in the curriculum and the research program, should provide trainees with a solid preparation to participate in the multidisciplinary research teams of future biomedical research. (END OF ABSTRACT)

描述（由申请人提供）：我们提出了一个多学科研究培训计划的创建，该计划将整合犹他大学领先的临床和基本研究科学家的专业知识，以利用动物模型来研究心血管，肾脏和肺部疾病的遗传机制。我们将提供博士后培训（临床科学家或博士学位），研究生培训以及使用动物来研究涉及疾病的基因和途径的短期培训，其主要目标是改善诊断和鉴定新药物以治疗常见的心血管，肾脏，肾脏，肾脏疾病和肺部疾病。专业知识不仅必须在产生遗传变化的动物方面发展，而且还必须在表征和分析其表型方面。受训者将在基因操纵，定量遗传学，功能基因组学，生物化学，生理学，成像，行为，生物信息学和统计学中进行全面研究，以在常见疾病的遗传学中进行全面研究所需的全面研究。 Thirty six faculty members from clinical and basic sciences departments will serve as preceptors for the trainees, drawn on one hand from the Clinical Divisions or Departments of Cardiology, Endocrinology, Hematology, Nephrology, Pulmonary Division, Pediatrics, and Medical Genetics, and on the other hand from the Basic Sc​​iences Departments or Divisions of Human Genetics, Biochemistry, Medical Informatics, Genetic流行病学，生物学，计算机科学和数学。在大学的研究生和研究生级别的培训计划的教学部分已经在大学中。通过临床和基础科学系的教师对个人学生进行双重指导，以及课程和研究计划中发展的观点，应为受训者提供扎实的准备，以参与未来生物医学研究的多学科研究团队。 （抽象的结尾）