Behavior Treatment for Chronic PTSD

慢性创伤后应激障碍的行为治疗

• 批准号: 7210353
• 负责人: DEBORAH C BEIDEL
• 金额: $ 10.99万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-10 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7210353
• 关键词: behavior therapy; behavioral /social science research tag; clinical research; human subject; human therapy evaluation; longitudinal human study; mental health education; patient oriented research; posttraumatic stress disorder; stress management; veterans

DESCRIPTION (provided by applicant): Post-traumatic stress disorder (PTSD), a severe and chronic anxiety disorder that follows traumatic experiences (e.g., combat, physical, and sexual assault), is characterized by acute symptoms of re-experiencing, emotional numbing, avoidance, hyperarousal, and severe impairment in social functioning. There is lifetime prevalence, as high as 14% in the general population and over 30% among combat veterans. Intensive exposure therapy reduces the hallmark features of chronic PTSD (e.g., intrusions, physiological reactivity) and much of the associated general anxiety, and currently is considered the psychosocial treatment of choice. However, exposure therapy does not reduce the "negative" symptoms of PTSD (e.g., avoidance, skill deficits, social isolation, interpersonal difficulties, anger control). Trauma Management Therapy (TMT), a multi-component behavioral treatment for chronic combat-related PTSD addresses all aspects of the clinical syndrome, using a combination of patient education, exposure therapy, social skills training (including emotional management) and systematic homework assignments. Preliminary evidence shows that overall TMT results in broad improvement across the wide spectrum of PTSD symptoms in veterans treated within the VA. This application is the next step in the evaluation of the efficacy of TMT. Specifically, this project is a prospective randomized study comparing TMT to Exposure Therapy only for treatment of chronic PTSD in combat veterans within the VA. Forty-eight subjects will be recruited from VA Medical Centers in Washington, D.C. Treatment will be administered over a 17-week period (active treatment phase); and subjects will be followed for an additional 12-months (follow-up phase) to ascertain long-term effects of treatment across four domains of functioning: (1) core PTSD symptoms; (2) social and emotional function; (3) symptoms of other psychiatric conditions (e.g., depression); and (4) treatment credibility and satisfaction. This application is submitted under the R21 (Exploratory/Developmental Grants) Mechanism.

描述（由申请人提供）：创伤后应激障碍（PTSD）是一种严重而慢性的焦虑症，遵循创伤经历（例如战斗，身体和性侵犯），其特征是重新经历，情绪麻木，避免，过度和过度症和社交功能的严重损害的急性症状。 终身患病率高达14％，在战斗退伍军人中超过30％。 强化暴露疗法降低了慢性PTSD的标志特征（例如，入侵，生理反应性）和许多相关的一般焦虑，目前被认为是选择的心理社会疗法。 但是，暴露疗法并不能减少PTSD的“负面”症状（例如，回避，技能缺陷，社会隔离，人际交往困难，控制愤怒）。 Trauma Management Therapy（TMT）是一种用于慢性战斗相关PTSD的多组分行为治疗，使用患者教育，暴露疗法，社交技能培训（包括情绪管理）和系统家庭作业和系统作业的结合，解决了临床综合征的各个方面。 初步证据表明，总体TMT在VA中接受的退伍军人中的PTSD症状广泛改善。 该应用程序是评估TMT功效的下一步。 具体而言，该项目是一项前瞻性随机研究，将TMT与暴露疗法仅用于治疗VA内战斗退伍军人的慢性PTSD。 将在华盛顿特区的VA医疗中心招募48名受试者。并将遵循额外的12个月（随访阶段），以确定在功能的四个领域的长期影响：（1）核心PTSD症状； （2）社会和情感功能； （3）其他精神病症状的症状（例如抑郁症）； （4）治疗信誉和满意度。 该申请根据R21（探索性/发展赠款）机制提交。