Neurobehavioral Status in Pediatric Epilepsy

小儿癫痫的神经行为状态

• 批准号: 6958279
• 负责人: MIYA R ASATO
• 金额: $ 15.92万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6958279
• 关键词: adolescence (12-20); behavior test; behavioral /social science research tag; brain morphology; child mental disorders; clinical research; cognition disorders; comorbidity; diffusion magnetic resonance imaging; epilepsy; executive function; functional magnetic resonance imaging; human subject; neuropathology; neuropsychological tests; partial seizure; patient oriented research; prefrontal lobe /cortex; short term memory; white matter

DESCRIPTION (provided by applicant): The proposed application will provide the applicant with the expertise required to establish a research career dedicated to characterizing the neurobiological basis of neurobehavioral co-morbidity in pediatric epilepsy. The candidate is a child neurologist who is proposing to obtain cross-disciplinary training from a developmental neuroscientist mentor, a panel of expert consultants in epilepsy, neuroimaging, psychiatry, neuropsychology and didactic sessions. We propose to use well-established neuroscience methods to investigate the neurobiological basis of neurobehavioral outcome in epilepsy. To characterize neurobehavioral status of children with complex partial seizures, benign focal epilepsy of childhood and healthy controls will be assessed using well-characterized behavioral tasks. To determine the neurobiological basis of neurobehavioral status a subgroup of subjects will also perform functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) studies. We hypothesize that cognitive and psychiatric impairment in children with complex partial seizures will be accompanied by a distinct change in brain activation patterns and increased variability in white matter integrity compared to control groups. These results will be crucial for developing a neurobiological model of neurobehavioral dysfunction in epilepsy that can inform treatment. This training will enable the candidate to obtain unique cross-disciplinary training using neuroimaging to link child psychiatry with neurology.

描述（由申请人提供）：拟议的申请将为申请人提供建立研究职业所需的专业知识，该研究职业致力于表征儿科癫痫中神经行为合并症的神经生物学基础。候选人是一名儿童神经科医生，他提议从发育神经科学家的导师那里获得跨学科培训，这是癫痫，神经影像学，精神病学，神经心理学和教学课程专家顾问小组的跨学科培训。我们建议使用良好的神经科学方法研究癫痫中神经行为结局的神经生物学基础。为了表征患有复杂部分癫痫发作的儿童的神经行为状态，将使用良好的行为任务评估儿童和健康对照的良性局灶性癫痫。为了确定神经行为状态的神经生物学基础，受试者的亚组还将执行功能性磁共振成像（fMRI）和扩散张量张量成像（DTI）研究。我们假设与对照组相比，患有复杂部分癫痫发作的儿童的认知和精神障碍将伴随着脑激活模式的明显变化，白质完整性的变异性增加。这些结果对于开发癫痫中神经行为功能障碍的神经生物学模型至关重要，该模型可以告知治疗。这项培训将使候选人能够使用神经影像来获得独特的跨学科培训，以将儿童精神病学与神经病学联系起来。