Cognitive Vulnerabilities in Daughters of Women with Panic Disorder

患有恐慌症的妇女的女儿的认知脆弱性

• 批准号: 7144691
• 负责人: KIMBERLY A WILSON
• 金额: $ 15.36万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7144691
• 关键词: adolescence (12-20); attention; behavior test; behavioral /social science research tag; clinical research; cognition; computers; disease /disorder proneness /risk; dyadic interaction; fear; female; human subject; interview; longitudinal human study; maternal behavior; mother child interaction; panic disorder; patient oriented research; personal log /diary; psychopathology; women' s health; adolescence (12-20); attention; behavior test; behavioral /social science research tag; clinical research; cognition; computers; disease /disorder proneness /risk; dyadic interaction; fear; female; human subject; interview; longitudinal human study; maternal behavior; mother child interaction; panic disorder; patient oriented research; personal log /diary; psychopathology; women' s health

DESCRIPTION (provided by applicant): The candidate seeks to use the award period to further develop into a successful independent researcher in the anxiety disorders field; to secure funding as an independent investigator; to add to her skill set new methods of assessing cognitive contributions to psychopathology; and to contribute to the anxiety disorder literature by prospectively investigating the contributions of cognitive bias on the development of anxiety sensitivity and anxiety symptoms in at-risk adolescents. Long term, the candidate anticipates this training will help facilitate an academic career with a focus on anxiety disorder mechanisms and prevention. The research development plan will foster those goals by providing mentorship from leaders in the field, structured seminars through the Departments of Psychology, Psychiatry, Biology, and Education and The Center on Adolescence, and the opportunity to learn experientially by conducting a longitudinal investigation into cognitive vulnerabilities for anxiety. The environment has successfully fostered other junior researchers. In the research project, the candidate aims to test the contribution of cognitive biases to the development of anxiety in at-risk adolescent girls. Three hypotheses will be tested: 1) Adolescent daughters of women with histories of panic disorder will demonstrate greater threat-related cognitive vulnerabilities (i.e., attentional bias and anxiety sensitivity) than daughters of women with no psychiatric histories; 2) The relationship between maternal panic disorder and adolescent cognitive vulnerabilities will be partially mediated by maternal modeling of fear; and 3) Cognitive vulnerabilities will prospectively predict change in panic-related anxiety symptoms 2 years after initial assessment. Two hundred dyads (100 pairs with panic mother and 100 control pairs) will be assessed yearly three times. Evaluation will consist of structured diagnostic interviews, validated self-report measures, and the dot probe task.

描述（由申请人提供）：候选人试图利用奖励期，以进一步发展成为焦虑症领域的独立研究人员；确保作为独立调查员的资金；为了增加她的技能，设定了评估对心理病理学的认知贡献的新方法；并通过前瞻性地研究认知偏见对高危青少年焦虑敏感性和焦虑症状的发展来促进焦虑症文献。从长远来看，候选人预计这项培训将有助于促进学术职业，重点是焦虑症机制和预防。研究开发计划将通过在心理学，精神病学，生物学和教育部门以及青春期中心提供领域的领导者，结构化研讨会，从而促进这些目标，并通过对焦虑的认知脆弱性进行纵向调查，从而实验学习。环境已成功培养了其他初级研究人员。在研究项目中，候选人旨在测试认知偏见对处于危险中的青春期女孩焦虑发展的贡献。将检验三个假设：1）与没有精神病学历史的女儿相比，与威胁有关的认知脆弱性（即注意偏见和焦虑敏感性）比具有威胁相关的认知脆弱性（即注意偏见和焦虑敏感性）更大的女儿； 2）母体恐慌症与青少年认知脆弱性之间的关系将由孕产妇的恐惧建模来部分介导； 3）认知脆弱性将在初次评估后2年前瞻性地预测恐慌相关焦虑症状的变化。每年将三百个二元组（100对与恐慌母亲和100对对照对）每年进行三次评估。评估将包括结构化的诊断访谈，经过验证的自我报告措施和DOT探测任务。