Gene Expression in Inflammatory Myopathies

炎症性肌病的基因表达

• 批准号: 6845240
• 负责人: STEVEN A GREENBERG
• 金额: $ 36.98万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6845240
• 关键词: artificial immunosuppression; biopsy; clinical research; disease /disorder classification; gene expression; human subject; microarray technology; model; model design /development; myositis; oligonucleotides; pathologic process; phenotype; serial analysis of gene expression

DESCRIPTION (provided by applicant): The goals of Gene Expression in Inflammatory Myopathies are: (1) to characterize patterns of muscle gene expression through the use of DNA microarrays among adult patients with distinct subtypes of inflammatory myopathies and correlate these patterns with clinical phenotypes, and (2) to formulate hypotheses relevant to the pathogenesis of the inflammatory myopathies. High-density oligonucleotide microarrays will be used to assay gene expression in muscle biopsy specimens from patients with inflammatory myopathies. These patients will be phenotypically well described and known to the clinical investigators of this proposal. Data analysis of gene expression profiles will be linked to clinical data to refine disease classification and understand distinctions among and within the major subtypes of inflammatory myopathy. Analysis of differential gene expression will also provide clues to pathogenesis of these disorders. This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis.

描述（由申请人提供）：炎症性肌病中基因表达的目标是：（1）通过在具有不同亚型炎症性肌病亚型的成年患者中使用DNA微阵列来表征肌肉基因表达的模式，并将这些模式与临床表型相关联，并将这些模式与临床表型相关联，以及（2）与假设相关的疗法症状相关。 高密度寡核苷酸微阵列将用于测定来自炎性肌病患者的肌肉活检标本中的基因表达。 这些患者将在表型上得到很好的描述，并为该提案的临床研究者所熟知。 基因表达谱的数据分析将与临床数据有关，以完善疾病分类并了解炎症性肌病的主要亚型之间和内部的区别。 差异基因表达的分析还将为这些疾病的发病机理提供线索。 这项工作可以为这些疾病提供进一步的诊断方法，并有助于理解其发病机理。

项目成果

Theories of the pathogenesis of inclusion body myositis.

• DOI: 10.1007/s11926-010-0102-5
• 发表时间: 2010-06
• 期刊: CURRENT RHEUMATOLOGY REPORTS
• 影响因子: 5
• 作者: Greenberg, Steven A

Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.

• DOI: 10.1002/ana.21805
• 发表时间: 2010-01
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Salaiegheh, Mohammad;Kong, Sek Won;Pinkus, Jack L.;Walsh, Ronan J.;Liao, Anne;Nazareno, Remedios;Amato, Anthony A.;Krastins, Bryan;Morehouse, Chris;Higgs, Brandon W.;Jallal, Bahlia;Yao, Yihong;Sarracino, David A.;Parker, Kenneth C.;Greenberg, Steven A.
• 通讯作者: Greenberg, Steven A.

How citation distortions create unfounded authority: analysis of a citation network.

• DOI: 10.1136/bmj.b2680
• 发表时间: 2009-07-20
• 期刊: BMJ (Clinical research ed.)
• 作者: Greenberg SA

Inclusion body myositis: review of recent literature.

包涵体肌炎：近期文献综述。

• DOI: 10.1007/s11910-009-0013-x
• 发表时间: 2009
• 期刊: Current neurology and neuroscience reports
• 影响因子: 5.6
• 作者: Greenberg,StevenA

Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis.

正常肌核和包涵体肌炎中“Tau”免疫反应性的性质。

• DOI: 10.1002/mus.21471
• 发表时间: 2009
• 期刊: Muscle & nerve
• 影响因子: 3.4
• 作者: Salajegheh,Mohammad;Pinkus,JackL;Nazareno,Remedios;Amato,AnthonyA;Parker,KennethC;Greenberg,StevenA
• 通讯作者: Greenberg,StevenA