Clinical Trials Network, Ohio Valley Node

临床试验网络，俄亥俄谷节点

• 批准号: 7126945
• 负责人: EUGENE C. SOMOZA
• 金额: $ 67.5万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126945
• 关键词: alcoholism /alcohol abuse; clinical research; clinical trials; cocaine; community health services; cooperative study; disulfiram; drug abuse chemotherapy; drug addiction; health services research tag; human subject; human therapy evaluation; patient oriented research; therapy compliance

DESCRIPTION (provided by applicant): The Ohio Valley Node (OVN) joined NIDA's Clinical Trials Network (CTN) four years ago, as one of the CTN's second wave of grantees. From the very beginning, the OVN has been a highly effective, enthusiastic, and energetic node that has excelled in providing scientific and administrative leadership, in collaborating with other nodes and with NIDA staff, and in disseminating information about evidence-based practice and the results of CTN studies. Moreover, the OVN has developed a model bi-directional relationship between its University of Cincinnati-affiliated Regional Research and Training Center (RRTC) and its six original ("core") community treatment programs (CTPs), which are located in Ohio, Indiana, Kentucky, and West Virginia. In this continuation application, the OVN proposes to enhance the geographical and cultural diversity of the CTN by expanding the OVN's Midwestern and Appalachian presence in the network and adding a Mississippi Delta component, via nine additional "protocol-specific" CTPs in five additional states. The fifteen OVN CTPs, which together treat more than 52,000 patients a year, will contribute significantly to the number and variety of potential participants for CTN studies. Each of the core OVN CTPs has participated in at least one CTN clinical trial and two survey studies and all six will continue to share in the administration of the node and in its development of research concepts and protocols. Although the new protocol-specific CTPs will play a more limited role, they are looking forward with enthusiasm to participating in appropriate clinical trials, providing an expanded and enriched patient population to the CTN. During the OVN's first four years in the CTN, we have immersed ourselves fully in all of its activities. We have submitted nine protocol concepts, of which five were chosen for further development; two have been converted into full protocols, including one which is currently enrolling participants. We have been active in the national committees of the CTN, providing five committee chairs and authoring or contributing to many SOPs and "guidance" documents. Unique contributions by the OVN include a system used CTN-wide for monitoring and reporting on staff training requirements and accomplishments, a system for tracking the progress of CTN clinical trials, and a template used to standardize the organization of CTN node budgets. The sense of satisfaction we feel in these and other accomplishments, together with the urgency we feel to continue working on the important search for effective treatments for substance abuse, make us eager to continue the work we have begun.

描述（由申请人提供）： 四年前，俄亥俄州谷节点（OVN）加入了NIDA的临床试验网络（CTN），这是CTN的第二波受赠人之一。从一开始，OVN一直是一个非常有效，热情和充满活力的节点，在与其他节点和NIDA员工合作以及传播有关循证实践和CTN研究结果的信息方面都在提供科学和行政领导方面表现出色。此外，OVN已经建立了辛辛那提大学的区域研究与培训中心（RRTC）及其六个原始（“核心”）社区治疗计划（CTPS）之间的模型双向关系，该计划位于俄亥俄州，印第安纳州，肯塔基州，肯塔基州和西弗吉尼亚州。 在此连续应用中，OVN提议通过扩展OVN中西部和阿巴拉契亚在网络中的存在，并通过在其他五个其他州中扩大了九个其他“协议特异性” CTP，从而增强CTN的地理和文化多样性。每年有15个OVN CTP共同治疗超过52,000名患者，将为CTN研究的潜在参与者数量和种类做出重大贡献。每个核心OVN CTP都参加了至少一项CTN临床试验和两项调查研究，所有六项研究都将继续共享节点的管理以及其研究概念和协议的发展。尽管新的特定于协议的CTP将发挥更有限的作用，但他们对参加适当的临床试验的热情期待，为CTN提供了扩大且丰富的患者人群。 在OVN在CTN中的头四年中，我们将自己完全沉浸在其所有活动中。我们提交了九个协议概念，其中五个是为了进一步发展的。两个已转换为完整的协议，其中包括目前正在招募参与者的协议。我们一直活跃于CTN的国家委员会，提供五个委员会主席，并为许多SOP和“指导”文件贡献或贡献。 OVN的独特贡献包括一个用于监视和报告员工培训要求和成就的系统，跟踪CTN临床试验进度的系统，以及用于标准化CTN节点预算组织的模板。我们在这些成就和其他成就中感到满意的感觉，以及我们一直在继续为滥用药物滥用的有效治疗而努力的紧迫感，使我们渴望继续开始我们已经开始的工作。